Introduction Ulinastatin, a broad-spectrum serine protease inhibitor, has been widely used to
treat various diseases clinically. However, so far, the antinociceptive effect of ulinastatin …

Ulinastatin is a broad-spectrum protease inhibitor widely used for the treatment of various
inflammation-related diseases owing to its recognized excellent anti-inflammatory and …

Previous studies have shown that ulinastatin, an effective inhibitor of the inflammatory
response in clinical applications, can attenuate hyperalgesia in rodents. However, the …

Ulinastatin, a serine protease inhibitor, which has anti-inflammatory properties and
neuroprotective effects, is used to treat acute inflammatory disorders. Recent evidence …

Ulinastatin, a broad spectrum of serine protease inhibitor, has been found to alleviate
neuropathic pain (NPP). However, its mechanism is not completely clear. Here, a sciatic …

Ulinastatin (UTI) is a broad-spectrum serine protease inhibitor isolated and purified from
human urine with strong anti-inflammatory and cytoprotective actions, which is widely used …

Astrocyte activation plays a pivotal role in neuroinflammation, which contributes to neuronal
damage, so the inhibition of astrocyte activation may alleviate the progression of …

Background Nerve injury sometimes leads to chronic neuropathic pain associated with
neuroinflammation in the nervous system. In the case of chronic neuropathic pain, the …

Low back pain (LBP) has been a wide public health concern worldwide. Among the
pathogenic factors, intervertebral disc degeneration (IDD) has been one of the primary …

Background Due to the global prevalence of opioid drugs, postsurgical prescriptions can
lead to substantial opioid consumption, highlighting the increasing need for alternative …