Identifying a reliable biomarker may accelerate diagnosis of multiple sclerosis (MS) and lead
to early management of the disease. Accumulating evidence suggest that cerebrospinal fluid …

Background: Osteopontin (OPN) is a pleiotropic protein with important roles in inflammation
and immunity that has been suggested as a candidate biomarker for disease activity in …

Background: The cytokine osteopontin (OPN) is a potential key player in the
immunopathogenesis of multiple sclerosis (MS) and a candidate biomarker for disease …

Osteopontin (OPN) was suggested to have a role in the pathophysiology of MS and in bone
metabolism. However, we formerly reported increased presence of osteoporosis in MS …

Osteopontin (OPN) up-regulates pro-inflammatory cytokines from both T helper type 1 and T
helper type 17 cell pathways. We measured plasma OPN levels in Japanese multiple …

Osteopontin (OPN) is a pleiotropic integrin binding protein with functions in cell-mediated
immunity, inflammation, tissue repair, and cell survival. Recent studies have shown that OPN …

Osteopontin (OPN) is an inflammatory cytokine highly expressed in multiple sclerosis (MS)
plaques. In a previous work, we showed that four OPN polymorphisms form three haplotypes …

Osteopontin (OPN) has been identified as the most prominent cytokine-encoding gene
expressed within multiple sclerosis (MS) lesions. Recently, we demonstrated that OPN …

Osteopontin (OPN) is a proinflammatory marker produced by systemic immune and central
nervous system (CNS) resident cells. We examined, if the level of OPN in the cerebrospinal …

Osteopontin (OPN) exhibits pleiotropic functions and abundant transcripts for OPN are
present in brains of patients with multiple sclerosis (MS). The aim of this study was to …