Osteopontin (OPN) as a CSF and blood biomarker for multiple sclerosis: A systematic review and meta-analysis
Identifying a reliable biomarker may accelerate diagnosis of multiple sclerosis (MS) and lead
to early management of the disease. Accumulating evidence suggest that cerebrospinal fluid …
to early management of the disease. Accumulating evidence suggest that cerebrospinal fluid …
Evaluation of circulating osteopontin levels in an unselected cohort of patients with multiple sclerosis: relevance for biomarker development
P Kivisäkk, BC Healy, K Francois… - Multiple Sclerosis …, 2014 - journals.sagepub.com
Background: Osteopontin (OPN) is a pleiotropic protein with important roles in inflammation
and immunity that has been suggested as a candidate biomarker for disease activity in …
and immunity that has been suggested as a candidate biomarker for disease activity in …
Osteopontin concentrations are increased in cerebrospinal fluid during attacks of multiple sclerosis
L Börnsen, M Khademi, T Olsson… - Multiple Sclerosis …, 2011 - journals.sagepub.com
Background: The cytokine osteopontin (OPN) is a potential key player in the
immunopathogenesis of multiple sclerosis (MS) and a candidate biomarker for disease …
immunopathogenesis of multiple sclerosis (MS) and a candidate biomarker for disease …
The role of osteopontin: a shared pathway in the pathogenesis of multiple sclerosis and osteoporosis?
A Altıntaş, G Saruhan-Direskeneli, G Benbir… - Journal of the …, 2009 - Elsevier
Osteopontin (OPN) was suggested to have a role in the pathophysiology of MS and in bone
metabolism. However, we formerly reported increased presence of osteoporosis in MS …
metabolism. However, we formerly reported increased presence of osteoporosis in MS …
Plasma osteopontin levels are associated with disease activity in the patients with multiple sclerosis and neuromyelitis optica
Y Shimizu, K Ota, R Ikeguchi, S Kubo… - Journal of …, 2013 - Elsevier
Osteopontin (OPN) up-regulates pro-inflammatory cytokines from both T helper type 1 and T
helper type 17 cell pathways. We measured plasma OPN levels in Japanese multiple …
helper type 17 cell pathways. We measured plasma OPN levels in Japanese multiple …
Plasma osteopontin levels in multiple sclerosis
M Comabella, I Pericot, R Goertsches, C Nos… - Journal of …, 2005 - Elsevier
Osteopontin (OPN) is a pleiotropic integrin binding protein with functions in cell-mediated
immunity, inflammation, tissue repair, and cell survival. Recent studies have shown that OPN …
immunity, inflammation, tissue repair, and cell survival. Recent studies have shown that OPN …
Osteopontin gene haplotypes correlate with multiple sclerosis development and progression
A Chiocchetti, C Comi, M Indelicato, L Castelli… - Journal of …, 2005 - Elsevier
Osteopontin (OPN) is an inflammatory cytokine highly expressed in multiple sclerosis (MS)
plaques. In a previous work, we showed that four OPN polymorphisms form three haplotypes …
plaques. In a previous work, we showed that four OPN polymorphisms form three haplotypes …
Osteopontin levels and increased disease activity in relapsing–remitting multiple sclerosis patients
MHJ Vogt, S Floris, J Killestein, DL Knol, M Smits… - Journal of …, 2004 - Elsevier
Osteopontin (OPN) has been identified as the most prominent cytokine-encoding gene
expressed within multiple sclerosis (MS) lesions. Recently, we demonstrated that OPN …
expressed within multiple sclerosis (MS) lesions. Recently, we demonstrated that OPN …
Osteopontin levels are associated with late-time lower regional brain volumes in multiple sclerosis
G Orsi, Z Hayden, T Cseh, T Berki, Z Illes - Scientific Reports, 2021 - nature.com
Osteopontin (OPN) is a proinflammatory marker produced by systemic immune and central
nervous system (CNS) resident cells. We examined, if the level of OPN in the cerebrospinal …
nervous system (CNS) resident cells. We examined, if the level of OPN in the cerebrospinal …
Genetic polymorphisms of osteopontin in association with multiple sclerosis in Japanese patients
M Niino, S Kikuchi, T Fukazawa, I Yabe… - Journal of …, 2003 - Elsevier
Osteopontin (OPN) exhibits pleiotropic functions and abundant transcripts for OPN are
present in brains of patients with multiple sclerosis (MS). The aim of this study was to …
present in brains of patients with multiple sclerosis (MS). The aim of this study was to …