The purpose of this study was to investigate whether 1%, 2% or 5% formalin injection
produce hypersensitivity with characteristics of the neuropathic pain induced by spinal nerve …

Subcutaneous (sc) injection of formalin induces a rapid and prolonged hyperalgesia across
widespread areas of the body. This hyperalgesic state involves a brain-to-spinal cord …

To determine whether initial nociceptive inputs caused by subcutaneous injection of formalin
into the hindpaw are necessary and/or sufficient for allodynic behavior and microglial …

The formalin test produces 2 well-known acute phases of nociceptive behavior. Recently, we
have shown that this same formalin test produces a third phase of nociceptive behavior …

Subcutaneous formalin injection is widely used as a nociceptive stimulus in the rat. This
procedure evokes overt behaviors that last about 90 minutes. However, little is known about …

The formalin test has been proposed as an animal model of pain produced by tissue injury.
Although biphasic nociceptive responses to formalin injection have been well documented …

Formalin (0.25, 0.5, 3, and 5%) injected into the knee joint of rats induced a dose-dependent
nociception that was featured by 2 phases of intense guarding behavior of the affected limb …

Previous work has demonstrated that pain facilitation can occur following injection of
subcutaneous irritants, such as formalin. Such studies have focused on apparent pain …

The present study has assessed the relationship between formalin-induced nociception and
formalin-induced inflammation by comparing the dose-related effects of anti-inflammatory …

Subcutaneous formalin injection has been used extensively to evaluate acute effects (over
several hours) of chemical nociceptive stimulation on nociceptive reflexes. Also, a persistent …