Background Repetitive C-fiber stimulation induces a state of facilitated processing of
sensory information in the dorsal horn, while chronic nerve compression gives rise to a …

This study evaluated the role of nitric oxide (NO) in spinal cord nociceptive transmission
during peripheral inflammation evoked by formalin injection into the rat paw, using N …

Intraplantar formalin injection produces early (Phase 1, 0-to 5-minute) and late (Phase 2, 15-
plus minutes after injection) nociceptive responses, including painlike behavior and …

Background Subcutaneous injection of dilute formalin in the hind paw of the rat produces a
biphasic nociceptive response. Initial C-fiber activity is accompanied by flinching of the paw …

The contribution of excitatory amino acids (EAAs) to the development of central sensitization
and persistent nociception in response to tissue injury in rats was examined following the …

Evidence is presented which suggests that central neural changes occur during the brief
early phase after subcutaneous formalin injection that are essential for the expression of …

Administration of formalin in rat paws results in stimulation of nociceptive pathways, which
leads to an increase in the excitability of neurons present in dorsal horn. This increased …

This study assesses the effects of peripheral or intrathecal pre-treatment or post-treatment
with µ, δ, κ and nociceptin/orphanin FQ (NOP) opioid receptor agonists (morphine, U-50488 …

Methods: In this study, we compared nociceptive behaviors induced by formalin injections
(2%, 4%, and 8%) into either glabrous skin (plantar surface) of the hind paw or hairy skin of …

Background In the present study we determined the role of transient receptor potential V1
channel (TRPV1) and acid-sensing ion channel 3 (ASIC3) in chronic nociception. Methods …