Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn's disease

MA Rosillo, M Sanchez-Hidalgo, A Cárdeno… - Biochemical …, 2011 - Elsevier
Current epidemiological and experimental studies support a beneficial role of dietary
polyphenols in several gastrointestinal diseases, including inflammatory bowel disease. The …

Modulation of signalling nuclear factor-κB activation pathway by polyphenols in human intestinal Caco-2 cells

B Romier, J Van De Walle, A During… - British Journal of …, 2008 - cambridge.org
Recent studies support beneficial effects of polyphenols in various chronic inflammatory
diseases, for example, the inflammatory bowel diseases. Inhibition of NF-κB activation by …

Ellagic acid protects Caco-2 cell monolayers against inflammation-induced permeabilization

DE Iglesias, E Cremonini, CG Fraga… - Free Radical Biology and …, 2020 - Elsevier
Chronic intestinal inflammation involves a cycle of oxidative stress, activation of redox
sensitive transcription factors, and barrier permeabilization. The latter can lead to systemic …

Intestinal anti-inflammatory activity of apigenin K in two rat colitis models induced by trinitrobenzenesulfonic acid and dextran sulphate sodium

C Mascaraque, R González, MD Suárez… - British Journal of …, 2015 - cambridge.org
Flavonoids are polyphenolic compounds that are widespread in nature, and consumed as
part of the human diet in significant amounts. The aim of the present study was to test the …

[HTML][HTML] Olive tree biophenols in inflammatory bowel disease: When bitter is better

T Larussa, M Imeneo, F Luzza - International journal of molecular …, 2019 - mdpi.com
The current therapeutic scenario for inflammatory bowel diseases (IBD) involves
aminosalicylates, corticosteroids, and immunomodulators, but concerns regarding their …

Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium

T Sergent, N Piront, J Meurice, O Toussaint… - Chemico-Biological …, 2010 - Elsevier
Phenolic compounds (PCs) are considered to possess anti-inflammatory properties and
therefore were proposed as an alternative natural approach to prevent or treat chronic …

Downregulation of iNOS and elevation of cAMP mediate the anti-inflammatory effect of glabridin in rats with ulcerative colitis

NE El-Ashmawy, NF Khedr, HA El-Bahrawy… - …, 2018 - Springer
Background Alternative medicine is widely accepted by public and becoming an attractive
approach for treatment of various diseases. Glabridin (Gla), a major flavonoid present in …

Inhibition of inflammatory mediators by polyphenolic plant extracts in human intestinal Caco-2 cells

B Romier-Crouzet, J Van De Walle, A During… - Food and Chemical …, 2009 - Elsevier
The mitogen-activated protein kinases (MAPK) and nuclear factor κB (NF-κB) are involved in
transduction cascades that play a key role in inflammatory response. We tested the ability of …

Polyphenols and inflammatory bowel disease: Natural products with therapeutic effects?

M Vaghari-Tabari, F Alemi, M Zokaei… - Critical Reviews in …, 2024 - Taylor & Francis
Inflammatory bowel disease (IBD) is a long-life disease with periods of recurrence and relief.
Oxidative stress plays an important role in the pathogenesis of this disease. Recent years' …

The role of dietary polyphenols in the management of inflammatory bowel disease

MH Farzaei, R Rahimi… - Current Pharmaceutical …, 2015 - ingentaconnect.com
Inflammatory bowel disease (IBD) is an idiopathic chronic, relapsing inflammation of the
bowel which is caused by dysregulation of the mucosal immune system. Polyphenols as the …