Direct activation of primary motor cortex during subthalamic but not pallidal deep brain stimulation

LA Johnson, J Wang, SD Nebeck, J Zhang… - Journal of …, 2020 - Soc Neuroscience
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus internus
(GPi) is an effective treatment for parkinsonian motor signs. Though its therapeutic …

Subthalamic nucleus stimulation modulates thalamic neuronal activity

W Xu, GS Russo, T Hashimoto, J Zhang… - Journal of …, 2008 - Soc Neuroscience
Deep brain stimulation (DBS) in the subthalamic nucleus (STN) is an effective tool for the
treatment of advanced Parkinson's disease. The mechanism by which STN DBS elicits its …

Activation of subthalamic neurons by contralateral subthalamic deep brain stimulation in Parkinson disease

HC Walker, RL Watts, CJ Schrandt… - Journal of …, 2011 - journals.physiology.org
Multiple studies have shown bilateral improvement in motor symptoms in Parkinson disease
(PD) following unilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) and …

Non-stationary discharge patterns in motor cortex under subthalamic nucleus deep brain stimulation

S Santaniello, EB Montgomery Jr, JT Gale… - Frontiers in integrative …, 2012 - frontiersin.org
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) directly modulates the basal
ganglia (BG), but how such stimulation impacts the cortex upstream is largely unknown …

Therapeutic deep brain stimulation disrupts movement-related subthalamic nucleus activity in parkinsonian mice

JS Schor, IG Montalvo, PWE Spratt, RJ Brakaj… - Elife, 2022 - elifesciences.org
Subthalamic nucleus deep brain stimulation (STN DBS) relieves many motor symptoms of
Parkinson's disease (PD), but its underlying therapeutic mechanisms remain unclear. Since …

External pallidal stimulation improves parkinsonian motor signs and modulates neuronal activity throughout the basal ganglia thalamic network

JL Vitek, J Zhang, T Hashimoto, GS Russo… - Experimental …, 2012 - Elsevier
Deep brain stimulation (DBS) of the internal segment of the globus pallidus (GPi) and the
subthalamic nucleus (STN) are effective for the treatment of advanced Parkinson's disease …

Stimulation of the subthalamic nucleus engages the cerebellum for motor function in parkinsonian rats

AC Sutton, KA O'Connor, JG Pilitsis… - Brain Structure and …, 2015 - Springer
Deep brain stimulation (DBS) is effective in managing motor symptoms of Parkinson's
disease in well-selected individuals. Recently, research has shown that DBS in the basal …

Single pulse stimulation of the human subthalamic nucleus facilitates the motor cortex at short intervals

R Hanajima, P Ashby, AM Lozano… - Journal of …, 2004 - journals.physiology.org
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for
Parkinson's disease (PD). The mechanism is poorly understood. High-frequency STN DBS …

[HTML][HTML] Evoked potentials reveal neural circuits engaged by human deep brain stimulation

SL Schmidt, DT Brocker, BD Swan, DA Turner, WM Grill - Brain stimulation, 2020 - Elsevier
Background Deep brain stimulation (DBS) is an effective therapy for reducing the motor
symptoms of Parkinson's disease, but the mechanisms of action of DBS and neural …

Cortical plasticity induction by pairing subthalamic nucleus deep-brain stimulation and primary motor cortical transcranial magnetic stimulation in Parkinson's disease

K Udupa, N Bahl, Z Ni, C Gunraj… - Journal of …, 2016 - Soc Neuroscience
Noninvasive brain stimulation studies have shown abnormal motor cortical plasticity in
Parkinson9s disease (PD). These studies used peripheral nerve stimulation paired with …