Susceptibility of mouse cochlear hair cells to cisplatin ototoxicity largely depends on sensory mechanoelectrical transduction channels both Ex Vivo and In Vivo
A Maruyama, Y Kawashima, Y Fukunaga, A Makabe… - Hearing Research, 2024 - Elsevier
Cisplatin, a highly effective chemotherapeutic drug for various human cancers, induces
irreversible sensorineural hearing loss as a side effect. Currently there are no highly …
irreversible sensorineural hearing loss as a side effect. Currently there are no highly …
[HTML][HTML] Preferential cochleotoxicity of cisplatin
P Prayuenyong, DM Baguley, CJ Kros… - Frontiers in …, 2021 - frontiersin.org
Cisplatin-induced ototoxicity in humans is more predominant in the cochlea than in the
vestibule. Neither definite nor substantial vestibular dysfunction after cisplatin treatment has …
vestibule. Neither definite nor substantial vestibular dysfunction after cisplatin treatment has …
[HTML][HTML] The mechanotransduction channel and organic cation transporter are critical for cisplatin ototoxicity in murine hair cells
Cisplatin is one of the most widely used chemotherapeutic drugs across the world. However,
the serious ototoxic effects, leading to permanent hair cell death and hearing loss …
the serious ototoxic effects, leading to permanent hair cell death and hearing loss …
[HTML][HTML] Supporting cells and their potential roles in cisplatin-induced ototoxicity
S Waissbluth, JC Maass, HA Sanchez… - Frontiers in …, 2022 - frontiersin.org
Cisplatin is a known ototoxic chemotherapy drug, causing irreversible hearing loss.
Evidence has shown that cisplatin causes inner ear damage as a result of adduct formation …
Evidence has shown that cisplatin causes inner ear damage as a result of adduct formation …
Early physiological and cellular indicators of cisplatin-induced ototoxicity
Y Chen, EC Bielefeld, JG Mellott, W Wang… - Journal of the …, 2021 - Springer
Cisplatin chemotherapy often causes permanent hearing loss, which leads to a multifaceted
decrease in quality of life. Identification of early cisplatin-induced cochlear damage would …
decrease in quality of life. Identification of early cisplatin-induced cochlear damage would …
Current understanding of membrane transporters as regulators or targets for cisplatin-induced hearing loss
KZ Pasquariello, JM Dey, JA Sprowl - Molecular Pharmacology, 2021 - ASPET
Cisplatin is a platinum-based drug, which remains among the most efficacious anticancer
treatment options. Unfortunately, use of cisplatin is hindered by dose-limiting toxicities …
treatment options. Unfortunately, use of cisplatin is hindered by dose-limiting toxicities …
[HTML][HTML] Modulation of copper transporters in protection against cisplatin-induced cochlear hair cell damage
H Jing-Chun, D Da-Lian, Y Dong-Zhen, J Hai-Yan… - Journal of Otology, 2011 - Elsevier
Cisplatin belongs to platinum-based drugs and is widely used in cancer chemotherapy.
Ototoxicity is one of the major dose limiting side-effects of cisplatin. For toxicity to occur …
Ototoxicity is one of the major dose limiting side-effects of cisplatin. For toxicity to occur …
Cisplatin ototoxicity in rat cochlear organotypic cultures
Ototoxicity is a dose-limiting side effect of chemotherapeutic treatment with cisplatin. In a
series of experiments on neonatal rat cochlear organotypic cultures, the extent of damage …
series of experiments on neonatal rat cochlear organotypic cultures, the extent of damage …
Mechanisms of cisplatin-induced ototoxicity and prevention
LP Rybak, D Mukherjea, V Ramkumar - Seminars in hearing, 2019 - thieme-connect.com
Cisplatin is a highly effective antineoplastic agent used to treat solid tumors. Unfortunately,
the administration of this drug leads to significant side effects, including ototoxicity …
the administration of this drug leads to significant side effects, including ototoxicity …
Effects of intratympanic steroid on cisplatin ototoxicity: an electrophysiological and ultrastructural study
Ototoxicity refers to the inner ear dysfunction caused by a drug or a chemical agent which
manifests as hearing loss or balance impairment, or both. Currently, antibiotics, diuretics …
manifests as hearing loss or balance impairment, or both. Currently, antibiotics, diuretics …