Niche anchorage and signaling through membrane‐bound Kit‐ligand/c‐kit receptor are kinase independent and imatinib insensitive
S Tabone‐Eglinger, Z Calderin‐Sollet… - The FASEB …, 2014 - Wiley Online Library
Kit ligand (KitL) and its tyrosine kinase receptor c‐kit are critical for germ cells, melanocytes,
mastocytes, and hematopoietic stem cells. Alternative splicing of KitL generates membrane …
mastocytes, and hematopoietic stem cells. Alternative splicing of KitL generates membrane …
Phosphatidylinositol 3′-kinase is required for growth of mast cells expressing the kit catalytic domain mutant
R Shivakrupa, A Bernstein, N Watring, D Linnekin - Cancer research, 2003 - AACR
The Kit receptor tyrosine kinase is critical for the growth and development of hematopoietic
cells, germ cells, and the interstitial cells of Cajal. Gain-of-function mutations in codon 816 of …
cells, germ cells, and the interstitial cells of Cajal. Gain-of-function mutations in codon 816 of …
Mechanism of activation of human c-KIT kinase by internal tandem duplications of the juxtamembrane domain and point mutations at aspartic acid 816
SY Kim, JJ Kang, HH Lee, JJ Kang, BK Kim… - Biochemical and …, 2011 - Elsevier
The proto-oncogene c-KIT receptor has been implicated as an essential component in the
activation of leukemic cells. The internal tandem duplication (ITD) of c-KIT has also been …
activation of leukemic cells. The internal tandem duplication (ITD) of c-KIT has also been …
KIT as a therapeutic target for non-oncological diseases
A Martinez-Anton, D Gras, A Bourdin, P Dubreuil… - Pharmacology & …, 2019 - Elsevier
KIT is a receptor tyrosine kinase that after binding to its ligand stem cell factor activates
signaling cascades linked to biological processes such as proliferation, differentiation …
signaling cascades linked to biological processes such as proliferation, differentiation …
[PDF][PDF] Amplification of a novel c-Kit activating mutation Asn^ 8^ 2^ 2-Lys in the Kasumi-1 cell line: at (8; 21)-Kit mutant model for acute myeloid leukemia
A Beghini, I Magnani, CB Ripamonti… - The Hematology …, 2002 - researchgate.net
Results: We identified in the Kasumi-1 cell line a novel Asn822Lys ligand-independent c-kit
activating mutation and demonstrated by semiquantitative PCR that the mutated allele is …
activating mutation and demonstrated by semiquantitative PCR that the mutated allele is …
C-KIT signaling in cancer treatment
K Stankov, S Popovic, M Mikov - Current pharmaceutical …, 2014 - ingentaconnect.com
Tumor progression is strongly associated with the activity of receptor tyrosine kinases
(RTKs) and their intracellular signal transduction pathways, which regulate several cell …
(RTKs) and their intracellular signal transduction pathways, which regulate several cell …
Inhibitors to overcome secondary mutations in the stem cell factor receptor KIT
H Kaitsiotou, M Keul, J Hardick… - Journal of medicinal …, 2017 - ACS Publications
In modern cancer therapy, the use of small organic molecules against receptor tyrosine
kinases (RTKs) has been shown to be a valuable strategy. The association of cancer cells …
kinases (RTKs) has been shown to be a valuable strategy. The association of cancer cells …
c-Kit—a hematopoietic cell essential receptor tyrosine kinase
CE Edling, B Hallberg - The international journal of biochemistry & cell …, 2007 - Elsevier
The receptor tyrosine kinase c-Kit is expressed in hematopoietic stem and progenitor cells
and in several non-hematopoietic tissues. In the hematopoietic system, c-Kit is critical for …
and in several non-hematopoietic tissues. In the hematopoietic system, c-Kit is critical for …
Necessity of tyrosine 719 and phosphatidylinositol 3′-kinase–mediated signal pathway in constitutive activation and oncogenic potential of c-kit receptor tyrosine …
K Hashimoto, I Matsumura, T Tsujimura… - Blood, The Journal …, 2003 - ashpublications.org
Substitution of valine (Val) for aspartic acid (Asp) at codon 814 constitutively activates
murine c-kit receptor tyrosine kinase (KIT), and Asp816Val mutation, corresponding to …
murine c-kit receptor tyrosine kinase (KIT), and Asp816Val mutation, corresponding to …
KITD816V Induces SRC-Mediated Tyrosine Phosphorylation of MITF and Altered Transcription Program in Melanoma
The oncogenic D816V mutation of the KIT receptor is well characterized in systemic
mastocytosis and acute myeloid leukemia. Although KITD816V has been found in …
mastocytosis and acute myeloid leukemia. Although KITD816V has been found in …