J. Neurochem.(2012) 120, 1084–1096. Abstract C3 ADP‐ribosyltransferase is a valuable
tool to study Rho‐dependent cellular processes. In the current study we investigated the …

Functional recovery and regeneration of corticospinal tract (CST) fibers following spinal cord
injury by compression or dorsal hemisection in mice was monitored after application of the …

C3 exoenzyme from Clostridium botulinum, specifically ADP-ribosylates small GTP-binding
proteins RhoA, B, and C. ADP-ribosylation causes functional inactivation of Rho proteins …

Peripheral nerve injuries are frequently seen in trauma patients and due to delayed nerve
repair, lifelong disabilities often follow this type of injury. Innovative therapies are needed to …

ABSTRACT Small GTPases of the Rho family play versatile roles in the formation and
development of axons and dendrites, effects often studied by the Rho‐inactivating C3 …

C3bot from Clostridium botulinum is a bacterial mono-ADP-ribosylating enzyme, which
transfers an ADP-ribose moiety onto the small GTPases Rho A/B/C. C3bot and the catalytic …

Peripheral nerve injury triggers the activation of the small GTPase RhoA in spinal motor and
peripheral sensory neurons. C3 transferase, an exoenzyme produced by Clostridium …

Formation of neurites and their differentiation into axons and dendrites requires precisely
controlled changes in the cytoskeleton. While small GTPases of the Rho family appear to be …

Many biological toxins are known to attack specific cell types, delivering their enzymatic
payloads to the cytosol. This process can be manipulated by molecular engineering of …

Botulinum neurotoxins (BoNTs) are toxins produced by the bacteria Clostridium botulinum,
the causing agent for botulism, in different serotypes, seven of which (A–G) are well …