Atrial fibrillation (AF) is a progressive disease characterized by cumulative
electrophysiological and structural remodeling of the atria. Cellular electrophysiological …

Atrial fibrillation (AF) is the most commonly sustained arrhythmia in clinical practice. Despite
the extensive studies, the pathophysiology of AF, however, remains incompletely …

Objectives: Atrial fibrillation (AF) is associated with a decrease in atrial ERP and ERP
adaptation to rate as well as changes in atrial conduction velocity. The cellular changes in …

DR Van Wagoner and JM Nerbonne. Molecular Basis of Electrical Remodeling in Atrial
Fibrillation. Journal of Molecular and Cellular Cardiology (2000) 32, 1101–1117. Atrial …

One of the most exciting developments in our understanding of atrial fibrillation (AF) over the
last several years has been the recognition that AF itself modifies atrial electrical properties …

Background Atrial fibrillation is self-perpetuating, suggesting that the tachyarrhythmia
causes electrophysiological changes that contribute to the progressive nature of the …

This review is focused on electrical adaptational processes in patients with chronic AF.
Cellular electrical remodeling includes shortening of action potential duration and effective …

The natural history of atrial fibrillation (AF) is characterized by a gradual worsening with time.
The recent finding that AF itself produces changes in atrial function and structure has …

Current evidence suggests that the pathogenesis of atrial fibrillation (AF) is multifactorial.
The observation that AF, once present, alters the electrophysiologic properties of the atrial …

Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice
representing a major health hazard. Owing to relative inefficacy and side effects of classic …