Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson–Gilford progeria syndrome mutation

SH Yang, X Qiao, LG Fong, SG Young - Biochimica et Biophysica Acta …, 2008 - Elsevier
Hutchinson–Gilford progeria syndrome (HGPS) is a progeroid syndrome characterized by
multiple aging-like disease phenotypes. We recently reported that a protein …

A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation

SH Yang, M Meta, X Qiao, D Frost… - The Journal of …, 2006 - Am Soc Clin Investig
Hutchinson-Gilford progeria syndrome (HGPS) is caused by the production of a truncated
prelamin A, called progerin, which is farnesylated at its carboxyl terminus. Progerin is …

A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model

BC Capell, M Olive, MR Erdos, K Cao… - Proceedings of the …, 2008 - National Acad Sciences
Hutchinson-Gilford progeria syndrome (HGPS) is the most dramatic form of human
premature aging. Death occurs at a mean age of 13 years, usually from heart attack or …

Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria

SH Yang, SY Chang, DA Andres, HP Spielmann… - Journal of lipid …, 2010 - ASBMB
Hutchinson-Gilford progeria syndrome (HGPS) is caused by the accumulation of a
farnesylated form of prelamin A (progerin). Previously, we showed that blocking protein …

Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson–Gilford progeria syndrome

LB Gordon, ME Kleinman, DT Miller… - Proceedings of the …, 2012 - National Acad Sciences
Hutchinson–Gilford progeria syndrome (HGPS) is an extremely rare, fatal, segmental
premature aging syndrome caused by a mutation in LMNA that produces the farnesylated …

Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated

SH Yang, DA Andres, HP Spielmann… - The Journal of …, 2008 - Am Soc Clin Investig
Hutchinson-Gilford progeria syndrome (HGPS), a rare disease that results in what appears
to be premature aging, is caused by the production of a mutant form of prelamin A known as …

Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin

SH Yang, SY Chang, S Ren, Y Wang… - Human molecular …, 2011 - academic.oup.com
Hutchinson–Gilford progeria syndrome (HGPS) is caused by a mutant prelamin A, progerin,
that terminates with a farnesylcysteine. HGPS knock-in mice (Lmna HG/+) develop severe …

Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition

J Marji, SI O'Donoghue, D McClintock, VP Satagopam… - PloS one, 2010 - journals.plos.org
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare premature aging disorder caused
by a de novo heterozygous point mutation G608G (GGC> GGT) within exon 11 of LMNA …

Presence and distribution of progerin in HGPS cells is ameliorated by drugs that impact on the mevalonate and mTOR pathways

CS Clements, MU Bikkul, W Ofosu, C Eskiw, D Tree… - Biogerontology, 2019 - Springer
Hutchinson–Gilford progeria syndrome (HGPS) is a rare, premature ageing syndrome in
children. HGPS is normally caused by a mutation in the LMNA gene, encoding nuclear lamin …

[HTML][HTML] Intermittent treatment with farnesyltransferase inhibitor and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts

D Gabriel, DD Shafry, LB Gordon, K Djabali - Oncotarget, 2017 - ncbi.nlm.nih.gov
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic condition associated with
mutations in the LMNA gene. This disease recapitulates some aspects of normal aging, such …