Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson–Gilford progeria syndrome mutation
SH Yang, X Qiao, LG Fong, SG Young - Biochimica et Biophysica Acta …, 2008 - Elsevier
Hutchinson–Gilford progeria syndrome (HGPS) is a progeroid syndrome characterized by
multiple aging-like disease phenotypes. We recently reported that a protein …
multiple aging-like disease phenotypes. We recently reported that a protein …
A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation
SH Yang, M Meta, X Qiao, D Frost… - The Journal of …, 2006 - Am Soc Clin Investig
Hutchinson-Gilford progeria syndrome (HGPS) is caused by the production of a truncated
prelamin A, called progerin, which is farnesylated at its carboxyl terminus. Progerin is …
prelamin A, called progerin, which is farnesylated at its carboxyl terminus. Progerin is …
A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model
Hutchinson-Gilford progeria syndrome (HGPS) is the most dramatic form of human
premature aging. Death occurs at a mean age of 13 years, usually from heart attack or …
premature aging. Death occurs at a mean age of 13 years, usually from heart attack or …
Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria
SH Yang, SY Chang, DA Andres, HP Spielmann… - Journal of lipid …, 2010 - ASBMB
Hutchinson-Gilford progeria syndrome (HGPS) is caused by the accumulation of a
farnesylated form of prelamin A (progerin). Previously, we showed that blocking protein …
farnesylated form of prelamin A (progerin). Previously, we showed that blocking protein …
Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson–Gilford progeria syndrome
LB Gordon, ME Kleinman, DT Miller… - Proceedings of the …, 2012 - National Acad Sciences
Hutchinson–Gilford progeria syndrome (HGPS) is an extremely rare, fatal, segmental
premature aging syndrome caused by a mutation in LMNA that produces the farnesylated …
premature aging syndrome caused by a mutation in LMNA that produces the farnesylated …
Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated
SH Yang, DA Andres, HP Spielmann… - The Journal of …, 2008 - Am Soc Clin Investig
Hutchinson-Gilford progeria syndrome (HGPS), a rare disease that results in what appears
to be premature aging, is caused by the production of a mutant form of prelamin A known as …
to be premature aging, is caused by the production of a mutant form of prelamin A known as …
Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin
SH Yang, SY Chang, S Ren, Y Wang… - Human molecular …, 2011 - academic.oup.com
Hutchinson–Gilford progeria syndrome (HGPS) is caused by a mutant prelamin A, progerin,
that terminates with a farnesylcysteine. HGPS knock-in mice (Lmna HG/+) develop severe …
that terminates with a farnesylcysteine. HGPS knock-in mice (Lmna HG/+) develop severe …
Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition
J Marji, SI O'Donoghue, D McClintock, VP Satagopam… - PloS one, 2010 - journals.plos.org
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare premature aging disorder caused
by a de novo heterozygous point mutation G608G (GGC> GGT) within exon 11 of LMNA …
by a de novo heterozygous point mutation G608G (GGC> GGT) within exon 11 of LMNA …
Presence and distribution of progerin in HGPS cells is ameliorated by drugs that impact on the mevalonate and mTOR pathways
Hutchinson–Gilford progeria syndrome (HGPS) is a rare, premature ageing syndrome in
children. HGPS is normally caused by a mutation in the LMNA gene, encoding nuclear lamin …
children. HGPS is normally caused by a mutation in the LMNA gene, encoding nuclear lamin …
[HTML][HTML] Intermittent treatment with farnesyltransferase inhibitor and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts
D Gabriel, DD Shafry, LB Gordon, K Djabali - Oncotarget, 2017 - ncbi.nlm.nih.gov
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic condition associated with
mutations in the LMNA gene. This disease recapitulates some aspects of normal aging, such …
mutations in the LMNA gene. This disease recapitulates some aspects of normal aging, such …
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