The SecY complex: conducting the orchestra of protein translocation

K Dalal, F Duong - Trends in cell biology, 2011 - cell.com
Like the conductor of an orchestra, the Sec protein translocation channel is the platform
needed to bring together the many different players required for the constitutive and …

Mechanisms of Sec61/SecY-mediated protein translocation across membranes

E Park, TA Rapoport - Annual review of biophysics, 2012 - annualreviews.org
The Sec61 or SecY channel, a universally conserved protein-conducting channel,
translocates proteins across and integrates proteins into the eukaryotic endoplasmic …

Protein translocation by the Sec61/SecY channel

AR Osborne, TA Rapoport… - Annu. Rev. Cell Dev …, 2005 - annualreviews.org
The conserved protein-conducting channel, referred to as the Sec61 channel in eukaryotes
or the SecY channel in eubacteria and archaea, translocates proteins across cellular …

Translocation of proteins through the Sec61 and SecYEG channels

EC Mandon, SF Trueman, R Gilmore - Current opinion in cell biology, 2009 - Elsevier
The Sec61 and SecYEG translocation channels mediate the selective transport of proteins
across the endoplasmic reticulum and bacterial inner membrane, respectively. These …

Protein export through the bacterial Sec pathway

A Tsirigotaki, J De Geyter, A Economou… - Nature Reviews …, 2017 - nature.com
The general secretory (Sec) pathway comprises an essential, ubiquitous and universal
export machinery for most proteins that integrate into, or translocate through, the plasma …

The Sec translocon mediated protein transport in prokaryotes and eukaryotes

K Denks, A Vogt, I Sachelaru, NA Petriman… - Molecular membrane …, 2014 - Taylor & Francis
Protein transport via the Sec translocon represents an evolutionary conserved mechanism
for delivering cytosolically-synthesized proteins to extra-cytosolic compartments. The Sec …

Molecular mechanisms underlying the early stage of protein translocation through the Sec translocon

T Mori, R Ishitani, T Tsukazaki, O Nureki, Y Sugita - Biochemistry, 2010 - ACS Publications
The Sec translocon, a protein-conducting channel, consists of a heterotrimeric complex
(SecYEG in bacteria and Sec61αβγ in eukaryotes) that provides a pathway for secretary …

Bacterial protein translocation requires only one copy of the SecY complex in vivo

E Park, TA Rapoport - Journal of Cell Biology, 2012 - rupress.org
The transport of proteins across the plasma membrane in bacteria requires a channel
formed from the SecY complex, which cooperates with either a translating ribosome in …

Sec-dependent protein translocation across biological membranes: evolutionary conservation of an essential protein transport pathway

K Stephenson - Molecular membrane biology, 2005 - Taylor & Francis
All living organisms, no matter how simple or complex, possess the ability to translocate
proteins across biological membranes and into different cellular compartments. Although a …

Protein translocation through the Sec61/SecY channel

Z Cheng - Bioscience Reports, 2010 - portlandpress.com
Special codes are embedded in the primary sequence of newly synthesized proteins to
determine their final destination. Protein translocation across biological membranes requires …