G-quadruplexes have gained prominence over the past two decades for their role in gene
regulation, control of anti-tumour activity and ageing. The physiological relevance and …

Accumulating evidence has linked G-quadruplex structures to a number of biological
processes in vivo, including DNA replication, transcription, and genomic maintenance …

G-quadruplexes are non-Watson-Crick four-stranded nucleic acid structures. Recent
evidence points toward their existence in vivo and their implication in various biological …

Nucleic acid sequences able to adopt a G-quadruplex conformation are overrepresented
within the human genome. This evidence strongly suggests that these genomic regions …

The research on the G-quadruplex DNAs has received much attention in recent years and
numerous reports appeared probing their detection, structure, stability, reactivity, selectivity …

G-quadruplexes are non-canonical nucleic acid structures formed by guanine-rich DNA or
RNA sequences. In recent decades, an increasing number of evidences have suggested …

The G-quadruplex structure is a non-canonical secondary DNA motif that is built from planar
tetrads of guanine residues stabilized by Hoogsteen-type hydrogen bonding. Bioinformatics …

G-quadruplexes, a family of tetraplex helical nucleic acid topologies, have emerged in
recent years as novel targets, with untapped potential for anticancer research. Their …

G-quadruplexes turned out to be important targets for the development of novel targeted
anticancer/antiviral therapies. More than 3000 G-quadruplex small-molecule ligands have …

Guanine-rich nucleic acids can fold into non-canonical DNA secondary structures called G-
quadruplexes. The formation of these structures can interfere with the biology that is crucial …