Angiogenesis is the propelling force for tumor growth and metastasis, and antiangiogenic
therapy represents one of the most promising modalities for cancer treatment. CD105 …

Among surface molecules expressed on endothelial cells, endoglin (CD105) is emerging as
a prime vascular target for antiangiogenetic cancer therapy. CD105 is a cell membrane …

Angiogenesis is crucial for tumor development and progression, and antiangiogenetic
therapy represents a promising approach for cancer treatment. Thus, the in-depth …

Abstract CD105 (endoglin), a receptor for transforming growth factor (TGF) β1 and β3 in
vascular endothelial cells, is highly up‐regulated in blood vessels of tissues where …

Antibody targeting of tumor-associated vasculature is a promising therapeutic approach in
human cancer; however, a specific cell membrane marker for endothelial cells of tumor …

Targeting of tumor vasculature is a promising strategy for cancer treatment. Among
endothelial cell markers, Endoglin, a cell membrane glycoprotein, is emerging as an …

Endoglin/CD105 is well acknowledged as being the most reliable marker of proliferation of
endothelial cells, and it is overexpressed on tumour neovasculature. Our current knowledge …

Endoglin (CD105) is an accessory receptor for transforming growth factor beta (TGF-β) and
its expression is up-regulated in actively proliferating endothelial cells. Endoglin has been …

CD146 is a cell adhesion molecule (CAM) that is primarily expressed at the intercellular
junction of endothelial cells. CD146 was originally identified as a tumor marker for …

The goal of our study was to raise monoclonal antibodies (mAbs) against endothelial cell—
surface proteins specific for tumor vasculature. Here, we describe the generation and …