B cells have multiple roles in immune activation and inflammation separate from their
capacity to produce antibodies. B cell depletion is currently under intense investigation as a …

SLE, a chronic, multisystem autoimmune disorder with a broad range of symptoms, involves
defective B cell selection and elimination of self-reactive B cells. B lymphocyte stimulator …

Objectives. To determine whether B cell activating factor of the tumour necrosis factor family
(BAFF) is involved in T cell-dependent B cell pathogenic autoantibody production in …

SS is an autoimmune condition characterized by exocrine gland destruction, autoantibody
production, immune complex deposition and systemic complications associated with …

Objective: To analyse B cell activating factor (BAFF) receptor (BAFF-R) expression on
peripheral lymphocytes from patients with primary Sjögren's syndrome (pSS) and systemic …

The B cell activating factor (BAFF) inhibitor, belimumab, is the first biologic drug approved for
the treatment of SLE, and exhibits modest, but durable, efficacy in decreasing disease flares …

Rheumatoid arthritis (RA) is a common autoimmune disease that is marked by a systemic
inflammatory reaction and joint erosions. Elevated levels of B cell activating factor (BAFF) …

Objective Elevated levels of BAFF and APRIL are characteristic of patients with systemic
lupus erythematosus (SLE). The reasons for enhanced cytokine production are not well …

BAFF and APRIL are TNF-like cytokines that support survival and differentiation of B cells.
The early appreciation that overexpression of BAFF leads to B cell expansion and a lupus …

BAFF [B‐cell activating factor belonging to the tumor necrosis factor (TNF) family] is a ligand
that is required for peripheral B‐cell survival and homeostasis. In addition to mediating B …