The serous acini of airway submucosal glands are important for fluid secretion in the lung.
Serous cells are also sites of expression of the cystic fibrosis transmembrane conductance …

Airway submucosal glands are sites of high expression of the cystic fibrosis transmembrane
conductance regulator (CFTR) Cl− channel and contribute to fluid homeostasis in the lung …

Airway submucosal glands contribute to airway surface liquid (ASL) composition and
volume, both important for lung mucociliary clearance. Serous acini generate most of the …

Airway submucosal glands are important sites of cystic fibrosis transmembrane conductance
regulator (CFTR) chloride (Cl−) channel expression and fluid secretion in the airway …

Cystic fibrosis (CF) airway disease arises from defective innate defenses, especially
defective mucus clearance of microorganisms. Airway submucosal glands secrete most …

Cytoplasmic Ca 2+ is a master regulator of airway physiology; it controls fluid, mucus, and
antimicrobial peptide secretion, ciliary beating, and smooth muscle contraction. The focus of …

Key points• The mechanisms of anion and fluid transport by airway submucosal glands are
not well understood and may differ from those in surface epithelium.• The Calu‐3 cell line is …

Cystic fibrosis (CF), which is caused by mutations in CFTR, affects many tissues, including
the lung. Submucosal gland serous acinar cells are primary sites of fluid secretion and …

Submucosal glands are the primary source of airway mucus, a critical component of lung
innate defenses. Airway glands are defective in cystic fibrosis (CF), showing a complete …

Using cell culture models, we have investigated the relative importance of cystic fibrosis
transmembrane conductance regulator (CFTR) and calcium-activated chloride channels …