The strategies available for treating salivary gland hypofunction are limited because
relatively little is known about the secretion process in humans. An initial microarray screen …

Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance
regulator (CFTR) Cl− channel, which mediates transepithelial Cl− transport in a variety of …

SPOC1 airway goblet cells secrete mucin in response to P2Y2 receptor agonists and to
secretagogues, phorbol 12‐myristate 13‐acetate (PMA) and ionomycin, which mobilize …

Human airways and glands express the anion channel cystic fibrosis transmembrane
conductance regulator, CFTR, and the epithelial Na+ channel, ENaC. Cystic fibrosis (CF) …

The standard patch-clamp technique was employed on enzymatically digested acinar cells
of submucosal glands isolated from feline trachea. ATP (-10 (-3) M) evoked bidirectional …

The activity of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) can be
mediated by surface G protein–coupled receptors such as the β2-adrenergic receptor. In this …

The Calu‐3 human cell line exhibits features of submucosal gland serous cells and secretes
HCO3−. The aim of this study was to identify the HCO3− transporters present in these cells …

Fluid and macromolecule secretion by submucosal glands in mammalian airways is
believed to be important in normal airway physiology and in the pathophysiology of cystic …

Of 12 cell lines derived from human lung cancers, only Calu-3 cells showed high
transepithelial resistance (Rte) and increases in short-circuit current (Isc) in response to …

Most airway mucus is produced by submucosal glands in response to neural signals. Gland
mucus traps microbes, inhibits their replication, and clears them from the airways. In cystic …