Abstract Purpose The BRCA1 and BRCA2 (BRCA) genes are heavily involved in
mammalian cell DNA repair processes. Germline pathogenic mutations in BRCA increase …

(1) Background: Individuals with BRCA1/2 gene mutations are at increased risk of breast
and ovarian cancer. The prevalence of BRCA1/2 mutations varies by race and ethnicity, and …

Background: BRCA1 and BRCA2 are high-penetrance inherited genes; different founder
mutations have been reported in various areas and races. By using trial registration data …

Objectives To investigate and analyze the BRCA mutations in Korean ovarian cancer
patients with or without family history and to find founder mutations in this group …

Purpose The National Comprehensive Cancer Network (NCCN) has proposed guidelines
for the genetic testing of the BRCA1 and BRCA2 genes, based on studies in western …

Purpose We provide evidence for the reclassification of the BRCA1: c. 5017_5019del variant
by presenting the clinicopathological characteristics, clinical outcomes, and family history of …

Background There is an increasing amount of data from Latin America on the
characterization of BRCA variants; however, there is limited information from Peru. We …

Tumor suppressor genes BRCA 1 and BRCA 2 are the two main breast and ovarian cancer
susceptibility genes, and their genetic testing has been used to evaluate the risk of …

BRCA1/2 are cancer predisposition genes involved in hereditary breast and ovarian cancer
(HBOC). Mutation carriers display an increased sensitivity to inhibitors of poly (ADP‐ribose) …

Objectives Hereditary breast and ovarian cancer syndrome is chacterized with multiple
cases of breast cancer and/or ovarian cancer on the same side of the family. BRCA1/BRCA2 …