Abstract Background The BRCA1 and BRCA2 mutation spectrum and mutation detection
rates according to different family histories were investigated in 521 subjects from 322 …

There is limited knowledge about the BRCA1/2 mutational profile in Lithuania. We aimed to
define the full BRCA1 and BRCA2 mutational spectrum and the clinically relevant …

Background Breast cancer is the most common cancer among women worldwide. Here, we
report the prevalence of BRCA1/2 mutations in patients with high‐risk breast cancer from …

Objectives Breast and/or ovarian cancers are complex multifactorial diseases caused by
interaction of both genetic and non-genetic factors and characterized by predisposition to …

BRCA1 and BRCA2 as important DNA repair genes have been thoroughly investigated in
abundant studies. The potential relationships of BRCA1/2 pathogenic variants between …

Purpose: Germline mutations in either BRCA1 or BRCA2 genes are responsible for the
majority of hereditary breast and ovarian cancers. At present, over thousand distinct BRCA1 …

Mutations in the BRCA1 and BRCA2 genes profoundly increase the risk of developing
breast and/or ovarian cancer among women. To explore the contribution of BRCA1 and …

Pathogenic germline mutations in the BRCA1 gene predispose carriers to early onset breast
and ovarian cancer. Clinical genetic screening of BRCA1 often reveals variants with …

Background Mutations in the high penetrance breast and ovarian cancer susceptibility gene
BRCA1 account for a significant percentage of hereditary breast and ovarian cancer cases …

Purpose: The aim of this study is to further understand the status of BRCA1 and BRCA2
mutation among Chinese high-risk breast cancer patients in multiple-ethnic regions of …