Excision Repair of cis-Diamminedichloroplatinum(II)-induced Damage to DNA of Chinese Hamster Cells
HNA Fraval, JJ Roberts - Cancer research, 1979 - AACR
Platinum was lost from the DNA of cis-diamminedichloroplatinum (II)[cis-Pt (II)]-treated
exponentially growing Chinese hamster V79-379A cells with a half-life of 28 hr. By contrast …
exponentially growing Chinese hamster V79-379A cells with a half-life of 28 hr. By contrast …
Influence of cis-Diamminedichloroplatinum(II) on DNA Synthesis and Cell Cycle Progression in Excision Repair Proficient and Deficient Chinese Hamster Ovary Cells
CM Sorenson, A Eastman - Cancer research, 1988 - AACR
DNA has been implicated as the critical intracellular target for cis-diamminedichloroplatinum
(II)(cis-DDP) action. Inhibition of DNA synthesis is a consequence of platination and has …
(II)(cis-DDP) action. Inhibition of DNA synthesis is a consequence of platination and has …
The interaction of antitumour platinum compounds with cellular DNA in cultured cells and animal tissues: relationship to DNA cellular repair processes
JJ Roberts, HNA Fraval - Biochimie, 1978 - Elsevier
Hela and Chinese hamster cells in the G 1 phases of their cell cycles are more sensitive to
treatment with cis platinum (II) diammine dichloride (cis Pt (II)) than cells in other phases of …
treatment with cis platinum (II) diammine dichloride (cis Pt (II)) than cells in other phases of …
DNA Cross-Linking and Cytotoxicity Induced by cis-Diamminedichloroplatinum(II) in Human Normal and Tumor Cell Lines
G Laurent, LC Erickson, NA Sharkey, KW Kohn - Cancer Research, 1981 - AACR
We have studied the cytotoxicity and DNA cross-linking induced by cis-
diamminedichloroplatinum (II)(cis-Pt) in a normal, a simian virus 40-transformed, and eight …
diamminedichloroplatinum (II)(cis-Pt) in a normal, a simian virus 40-transformed, and eight …
Quenching of DNA:Platinum(II) Monoadducts as a Possible Mechanism of Resistance to cis-Diamminedichloroplatinum(II) in L1210 Cells
K Micetich, LA Zwelling, KW Kohn - Cancer Research, 1983 - AACR
A line of mouse leukemia L1210 cells resistant to cis-diamminedichloroplatinum (II)(cis-
DDP) was compared with its parent cell line in order to determine whether the sensitivity …
DDP) was compared with its parent cell line in order to determine whether the sensitivity …
Repair of cis-platinum (II) diammine dichloride-induced DNA damage and cell sensitivity
JJ Roberts, HNA Fraval - Cisplatin, 1980 - Elsevier
Publisher Summary This chapter discusses the relative sensitivities of different cell types;
cells in different stages of the cell cycle; and cells in different replicative states. These …
cells in different stages of the cell cycle; and cells in different replicative states. These …
Induction and repair of DNA cross-links in Chinese hamster ovary cells treated with various platinum coordination compounds in relation to platinum binding to DNA …
ACM Plooy, M van Dijk, PHM Lohman - Cancer research, 1984 - AACR
Several effects of four diamminechloroplatinum compounds (II and IV) in Chinese hamster
ovary cells were studied. The two cis-compounds [cis-diamminedichloroplatinum (II) and cis …
ovary cells were studied. The two cis-compounds [cis-diamminedichloroplatinum (II) and cis …
Walker rat carcinoma cells are exceptionally sensitive to cis-diamminedichloroplatinum (II)(cisplatin) and other difunctional agents but not defective in the removal of …
CJ Rawlings, JJ Roberts - Mutation Research/DNA Repair Reports, 1986 - Elsevier
Cisplatin binds to cellular macromolecules (DNA, RNA and protein) to the same extent in
wild-type Walker rat carcinoma cells and a variant sub-line of these cells resistant to cisplatin …
wild-type Walker rat carcinoma cells and a variant sub-line of these cells resistant to cisplatin …
Differential Toxicity of cis- and trans-Diamminedichloroplatinum(II) toward Mammalian Cells: Lack of Influence of Any Difference in the Rates of Loss of Their DNA …
JJ Roberts, F Friedlos - Cancer research, 1987 - AACR
DNA-bound adducts formed by cis-or trans-diamminedichloroplatinum (II)(cis-DDP or trans-
DDP, respectively) have very different effects on DNA synthesis and cell cycle progression in …
DDP, respectively) have very different effects on DNA synthesis and cell cycle progression in …
Mechanism of cis-Diamminedichloroplatinum(II)-induced Cytotoxicity: Role of G2 Arrest and DNA Double-Strand Breaks
CM Sorenson, A Eastman - Cancer research, 1988 - AACR
DNA has been implicated as the critical target for cis-diamminedichloroplatinum (II)(cis-
DDP)-induced cytotoxicity. In vitro, DNA-platinum adducts inhibit DNA synthesis. An …
DDP)-induced cytotoxicity. In vitro, DNA-platinum adducts inhibit DNA synthesis. An …