Fluorine-containing compounds are widely used because they have properties required in
textiles and coatings for electronic, automotive, and outdoor products. However, fluorinated …

The carbon− fluorine bond is the strongest covalent bond in organic chemistry, yet
fluoroacetate dehalogenases can readily hydrolyze this bond under mild physiological …

Organofluorines are widely used in a variety of applications, ranging from pharmaceuticals
to pesticides and advanced materials. The widespread use of organofluorines also leads to …

Fluorinated compounds are widely used in the fields of molecular imaging, pharmaceuticals,
and materials. Fluorinated natural products in nature are rare, and the introduction of …

The introduction of fluorine atoms into organic molecules has received considerable
attention as these organofluorines have often found widespread applications in bioorganic …

Fluorochemicals are a widely distributed class of compounds and have been utilized across
a wide range of industries for decades. Given the environmental toxicity and adverse health …

Fluorine forms the strongest single bond to carbon with the highest bond dissociation energy
among natural products. However, fluoroacetate dehalogenases (FADs) have been shown …

The catalytic mechanisms of fluoroacetate dehalogenase (FAcD) toward substrates
fluoroacetate and chloroacetate were studied by a combined quantum mechanics/molecular …

The biodegradability of many fluorinated compounds is limited due to the robustness of the
C F bond. Recently, experimental studies suggested the potential involvement of …

The capacity to defluorinate polyfluorinated organic compounds is a rare phenotype in
microbes but is increasingly considered important for maintaining the environment. New …