6. Lutterotti N von, Catanzaro DF, Sealey JE, Laragh JH (1994) Renin is not synthesized by
cardiac and extrarenal vascular tissues. A review of experimental evidence. Circulation 89 …

Renin was first isolated in the kidney by Tigerstedt and Bergman over 100 years ago. Almost
50 additional years were necessary to isolate the renin substrate angiotensinogen and to …

The renin-angiotensin system (RAS) has been extensively studied in the past decades as an
important mediator of hypertension and hypertensive end-organ damage. Originally, the …

Hypertension is one of the most important risk factors and a leading cause of death from
cardiovascular and cerebrovascular diseases. Based on numerous previous studies …

The primary aim of this book is to provide a topical and timely forum for the critical appraisal
of an area of renin-angiotensin system (RAS) research that is expanding rapidly. In this …

Several cardiac and renal diseases are attributed to a dysregulation of the renin-angiotensin
system. Renin, the rate-limiting enzyme of the renin-angiotensin system, has 2 isoforms. The …

It has been our pleasure to have been able to develop two special issues within the
International Journal of Molecular Sciences:(1) Renin-Angiotensin-Aldosterone System in …

Many articles have described the biochemistry of the renin-angiotensin system (RAS).
Simply put, renin and angiotensin-converting enzyme (ACE) produce angiotensin II, which …

Gene expression of the renin-angiotensin system in human kid... : Journal of Hypertension
Gene expression of the renin-angiotensin system in human kidney : Journal of …

The renin-angiotensin system (RAS) is compartmented between the circulating blood and
pericellular spaces. Whereas renin and its substrate diffuse easily from one compartment to …