[HTML][HTML] HIF-1α induces the epithelial-mesenchymal transition in gastric cancer stem cells through the Snail pathway
S Yang, Z Zhang, Y Hao, Y Zhao, F Qian, Y Shi, P Li… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Substantial evidence suggests that the epithelial-mesenchymal transition (EMT) phenotype
is associated with the invasive characteristics of cancer stem cells (CSCs), which possess …
is associated with the invasive characteristics of cancer stem cells (CSCs), which possess …
[HTML][HTML] Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner
J Lei, J Ma, Q Ma, X Li, H Liu, Q Xu, W Duan, Q Sun… - Molecular cancer, 2013 - Springer
Background Hypoxia plays a vital role in cancer epithelial to mesenchymal transition (EMT)
and invasion. However, it is not quite clear how hypoxia may contribute to these events …
and invasion. However, it is not quite clear how hypoxia may contribute to these events …
[HTML][HTML] Hypoxia-induced aggressiveness of pancreatic cancer cells is due to increased expression of VEGF, IL-6 and miR-21, which can be attenuated by CDF …
B Bao, S Ali, A Ahmad, AS Azmi, Y Li, S Banerjee… - PloS one, 2012 - journals.plos.org
Hypoxia is known to play critical roles in cell survival, angiogenesis, tumor invasion, and
metastasis. Hypoxia mediated over-expression of hypoxia-inducible factor (HIF) has been …
metastasis. Hypoxia mediated over-expression of hypoxia-inducible factor (HIF) has been …
[HTML][HTML] Effect of hypoxia on hypoxia inducible factor-1α, insulin-like growth factor I and vascular endothelial growth factor expression in hepatocellular carcinoma …
Q Liu, Z Xu, S Mao, W Chen, R Zeng… - Oncology …, 2015 - spandidos-publications.com
Hypoxic microenvironments and angiogenesis have been a focus of tumor research in
previous years. The aim of the the present study was to create a hypoxic model and observe …
previous years. The aim of the the present study was to create a hypoxic model and observe …
[HTML][HTML] Hypoxia inducible factor 1 (HIF-1) recruits macrophage to activate pancreatic stellate cells in pancreatic ductal adenocarcinoma
N Li, Y Li, Z Li, C Huang, Y Yang, M Lang… - International journal of …, 2016 - mdpi.com
Hypoxia inducible factor 1 (HIF-1) is a transcription factor composed of two subunits, namely,
HIF-1α and HIF-1β, in which HIF-1β is constitutively expressed. HIF-1 upregulates several …
HIF-1α and HIF-1β, in which HIF-1β is constitutively expressed. HIF-1 upregulates several …
HIF-3α promotes metastatic phenotypes in pancreatic cancer by transcriptional regulation of the RhoC–ROCK1 signaling pathway
X Zhou, X Guo, M Chen, C Xie, J Jiang - Molecular Cancer Research, 2018 - AACR
Hypoxia contributes to pancreatic cancer progression and promotes its growth and invasion.
Previous research principally focused on hypoxia-inducible factor-1 alpha (HIF-1α) and HIF …
Previous research principally focused on hypoxia-inducible factor-1 alpha (HIF-1α) and HIF …
[HTML][HTML] Hypoxia enhances cholangiocarcinoma invasion through activation of hepatocyte growth factor receptor and the extracellular signal‑regulated kinase …
T Vanichapol, K Leelawat… - Molecular medicine …, 2015 - spandidos-publications.com
Hypoxia is associated with tumor progression and poor prognosis in several cancer types.
The present study aimed to examine the contribution of hypoxia (1% O2) to cancer …
The present study aimed to examine the contribution of hypoxia (1% O2) to cancer …
Diffuse-type gastric cancer cells switch their driver pathways from FGFR2 signaling to SDF1/CXCR4 axis in hypoxic tumor microenvironments
H Kinoshita, M Yashiro, T Fukuoka… - …, 2015 - academic.oup.com
Cancer-associated fibroblasts (CAFs) have been considered to play an important role for
tumor progression of cancer. Solid tumors contain heterogeneous distribution of oxygen in …
tumor progression of cancer. Solid tumors contain heterogeneous distribution of oxygen in …
CAF-derived HGF promotes cell proliferation and drug resistance by up-regulating the c-Met/PI3K/Akt and GRP78 signalling in ovarian cancer cells
W Deying, G Feng, L Shumei, Z Hui, L Ming… - Bioscience …, 2017 - portlandpress.com
The tumour microenvironment is a highly heterogeneous entity that plays crucial roles in
cancer progression. As the most prominent stromal cell types, cancer-associated fibroblasts …
cancer progression. As the most prominent stromal cell types, cancer-associated fibroblasts …
Activation of PI3 kinase/Akt/HIF-1α pathway contributes to hypoxia-induced epithelial-mesenchymal transition and chemoresistance in hepatocellular carcinoma
M Jiao, KJ Nan - International journal of oncology, 2012 - spandidos-publications.com
Hypoxia is known to promote malignant progression and to induce chemoresistance in
cancer. However, the exact mechanisms driving hypoxia induced malignance remain …
cancer. However, the exact mechanisms driving hypoxia induced malignance remain …