Histamine H3 receptors were first described in the eighties but finally cloned four years ago.
They are G-protein coupled, mostly presynaptic, and are involved in the control of the …

The identification of histamine H3 (H3R) and H4 (H4R) receptors some years ago revived
interest in histamine research and exposed attractive perspectives for the potential …

Among the four G protein–coupled receptors (H1–H4) identified as mediators of the biologic
effects of histamine, the H3 receptor (H3R) is distinguished for its almost exclusive …

Advances in molecular biology have brought fresh impetus to the field of research into
histamine receptor ligands with the recent cloning of human histamine H3 and H4 receptors …

Histamine H3 receptors are found mostly in central nervous system involved in the
regulation of release of various neurotransmitters in brain. They have been implicated in …

Conclusions The discovery of the third histamine receptor and the design of highly selective
and potent ligands have not only clarified some aspects of histaminergic neurotransmission …

The histamine H3 receptor plays a regulatory role in the pre-synaptic release of histamine
and other neurotransmitters, making it an attractive target for CNS indications including …

The third histamine receptor was discovered in 1983 by a traditional pharmacological
approach, consisting of assessing the inhibitory effect of histamine on its own release from …

The histamine H3 receptor, first described in 1983 as a histamine autoreceptor and later
shown to also function as a heteroreceptor that regulates the release of other …

Since the cloning of the histamine H3 receptor cDNA in 1999 by Lovenberg and co-workers,
this histamine receptor has gained the interest of many pharmaceutical companies as a …