Publisher Summary In recent decades, obesity, bulimia, anorexia, and related eating
disorders have increased, leading to concern. Sweetness and other food tastes are merely …

BACKGROUND: Binge eating is associated with obesity and has been conceptualized as
“food addiction.” However, this view has received only inconsistent support in humans, and …

Infusion of a μ-opioid receptor (MOR) agonist into the nucleus accumbens (NAcc) drives
voracious food intake, an effect hypothesized to occur through increased tastant palatability …

Frontal cortical regions are activated by food-associated stimuli, and this activation appears
to be dysregulated in individuals with eating disorders. Nevertheless, frontal control of basic …

Endogenous opioids are involved in the hedonic aspects of eating. Opioid impairments and
alterations have been implicated in the pathophysiology of bulimia nervosa and binge …

Endogenous opioids, and in particular μ-opioid receptors, have been linked to hedonic and
rewarding mechanisms engaged during palatable food intake. The aim of this study was to …

Publisher Summary Obesity is caused by the consumption of excess calories. As such, it can
be viewed as a failure of homeostatic systems that control body weight or, more …

Objectives: We have previously shown that the combined consumption of fat and a sucrose
solution induces overeating, and there is evidence indicating that sucrose drinking directly …

Mu opioid receptor (MOR) signaling in the nucleus accumbens (NAcc) elicits marked
increases in the consumption of palatable tastants. However, the mechanism and circuitry …

Historically, studies of food intake regulation started with the hypothalamus and gradually
expanded to mesocorticolimbic regions, while studies of drug use began with …