New evidence linking obesity and food addiction

EC Cope, E Gould - Biological psychiatry, 2017 - biologicalpsychiatryjournal.com
Obesity rates have skyrocketed over the past few decades. In the United States,
approximately 35% of adults are now considered obese, with more than 60% categorized as …

Reward, dopamine and the control of food intake: implications for obesity

ND Volkow, GJ Wang, RD Baler - Trends in cognitive sciences, 2011 - cell.com
The ability to resist the urge to eat requires the proper functioning of neuronal circuits
involved in top-down control to oppose the conditioned responses that predict reward from …

Role of opiate peptides in regulating energy balance

RJ Bodnar, AS Levine - Neurobiology of Obesity, 2008 - experts.umn.edu
The endogenous opioid system, initially characterized over 30 years ago, is a primary
example of a multifunctional neural system involved in a wide range of basic homeostatic …

From taste hedonics to motivational drive: central µ-opioid receptors and binge-eating behaviour

PJ Nathan, ET Bullmore - International Journal of …, 2009 - academic.oup.com
Endogenous opioids and µ-opioid receptors (MORs) have long been implicated in the
mechanism of appetite control and, in particular, hedonic processes associated with food …

Principles of motivation revealed by the diverse functions of neuropharmacological and neuroanatomical substrates underlying feeding behavior

BA Baldo, WE Pratt, MJ Will, EC Hanlon… - Neuroscience & …, 2013 - Elsevier
Circuits that participate in specific subcomponents of feeding (eg, gustatory perception,
peripheral feedback relevant to satiety and energy balance, reward coding, etc.) are found at …

Intake of high-fat food is selectively enhanced by muopioid receptor stimulation within the nucleus accumbens

M Zhang, BA Gosnell, AE Kelley - Journal of Pharmacology and …, 1998 - ASPET
The present study was designed to further investigate the nature of feeding induced by
opioid stimulation of the nucleus accumbens through an examination of the effects of intra …

Mu opioid receptor antagonism in the nucleus accumbens shell blocks consumption of a preferred sucrose solution in an anticipatory contrast paradigm

Y Katsuura, SA Taha - Neuroscience, 2014 - Elsevier
Binge eating, a central feature of multiple eating disorders, is characterized by excessive
consumption occurring during discrete, often brief, intervals. Highly palatable foods play an …

Further developments in the neurobiology of food and addiction: update on the state of the science

NM Avena, JA Gold, C Kroll, MS Gold - Nutrition, 2012 - Elsevier
Over the past three decades, obesity has become a major public health crisis in the United
States. The prevalence of obesity in the United States and in other parts of the world has led …

Nucleus accumbens μ-opioids regulate intake of a high-fat diet via activation of a distributed brain network

MJ Will, EB Franzblau, AE Kelley - Journal of Neuroscience, 2003 - Soc Neuroscience
Endogenous opioid peptides within the nucleus accumbens, a forebrain site critical for the
regulation of reward-related behavior, are believed to play an important role in the control of …

Neurobiology of consummatory behavior: mechanisms underlying overeating and drug use

JR Barson, I Morganstern, SF Leibowitz - ILAR journal, 2012 - academic.oup.com
Consummatory behavior is driven by both caloric and emotional need, and a wide variety of
animal models have been useful in research on the systems that drive consumption of food …