[HTML][HTML] Current understanding of the cGAS-STING signaling pathway: Structure, regulatory mechanisms, and related diseases
J Pan, CJ Fei, Y Hu, XY Wu, L Nie, J Chen - Zoological Research, 2023 - ncbi.nlm.nih.gov
The innate immune system protects the host from external pathogens and internal damage
in various ways. The cGAS-STING signaling pathway, comprised of cyclic GMP-AMP …
in various ways. The cGAS-STING signaling pathway, comprised of cyclic GMP-AMP …
[HTML][HTML] cGAS-STING: insight on the evolution of a primordial antiviral signaling cassette
H Cai, JL Imler - Faculty Reviews, 2021 - ncbi.nlm.nih.gov
Stimulator of interferon genes (STING) functions in the cytosolic DNA-sensing pathway of
innate immunity in mammals. It is activated upon binding the cyclic dinucleotide 2′ 3 …
innate immunity in mammals. It is activated upon binding the cyclic dinucleotide 2′ 3 …
Control of innate immunity by the cGAS‐STING pathway
K Mosallanejad, JC Kagan - Immunology and cell biology, 2022 - Wiley Online Library
Within the cytoplasm of mammalian cells is a protein called cyclic GMP‐AMP synthase
(cGAS), which acts to defend against infection and other threats to the host. cGAS operates …
(cGAS), which acts to defend against infection and other threats to the host. cGAS operates …
The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer
T Li, ZJ Chen - Journal of Experimental Medicine, 2018 - rupress.org
Detection of microbial DNA is an evolutionarily conserved mechanism that alerts the host
immune system to mount a defense response to microbial infections. However, this detection …
immune system to mount a defense response to microbial infections. However, this detection …
Biochemistry, cell biology, and pathophysiology of the innate immune cGAS–cGAMP–STING pathway
In the decade since the discovery of the innate immune cyclic GMP–AMP synthase (cGAS)–
2′ 3′-cyclic GMP–AMP (cGAMP)–stimulator of interferon genes (STING) pathway, its …
2′ 3′-cyclic GMP–AMP (cGAMP)–stimulator of interferon genes (STING) pathway, its …
[HTML][HTML] The interactions between cGAS-STING pathway and pathogens
Cytosolic DNA is an indicator of pathogen invasion or DNA damage. The cytosolic DNA
sensor cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase …
sensor cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase …
Cyclic GMP–AMP as an endogenous second messenger in innate immune signaling by cytosolic DNA
K Kato, H Omura, R Ishitani… - Annual review of …, 2017 - annualreviews.org
The innate immune system functions as the first line of defense against invading bacteria
and viruses. In this context, the cGAS/STING [cyclic guanosine monophosphate (GMP) …
and viruses. In this context, the cGAS/STING [cyclic guanosine monophosphate (GMP) …
Evolutionary origins of cGAS-STING signaling
SR Margolis, SC Wilson, RE Vance - Trends in immunology, 2017 - cell.com
Detection of foreign nucleic acids is an important strategy for innate immune recognition of
pathogens. In vertebrates, pathogen-derived DNA is sensed in the cytosol by cGAS, which …
pathogens. In vertebrates, pathogen-derived DNA is sensed in the cytosol by cGAS, which …
[HTML][HTML] cGAS-STING pathway as a potential trigger of immunosenescence and inflammaging
CRR Schmitz, RM Maurmann, FTCR Guma… - Frontiers in …, 2023 - frontiersin.org
Aging is associated with an increased incidence of autoimmune diseases, despite the
progressive decline of immune responses (immunosenescence). This apparent paradox can …
progressive decline of immune responses (immunosenescence). This apparent paradox can …