It is well recognized that there are two androgens, namely testosterone (T) and
dihydrotestosterone (DHT); T plays an important role in the testis and muscle, and DHT is …

Growth of prostate cancer cells is dependent upon androgen stimulation of the androgen
receptor (AR). Dihydrotestosterone (DHT), the most potent androgen, is usually synthesized …

This review is triggered by recent developments that offer new explanations for the
mechanism of progression of prostate cancer to androgen independence. Established and …

BACKGROUND Blocking 5α‐reductase‐mediated testosterone conversion to
dihydrotestosterone (DHT) with finasteride or dutasteride is the driving hypothesis behind …

Publisher Summary This chapter discusses the molecular action of androgen in the normal
and neoplastic prostate. Androgens are steroid hormones that are required for normal male …

Introduction Prostate cancer constitutes a major health issue in Western countries where it is
now the most frequently diagnosed invasive tumour and second leading cause of cancer …

The metabolic functions of androgen receptor (AR) in normal prostate are circumvented in
prostate cancer (PCa) to drive tumor growth, and the AR also can acquire new growth …

The androgen receptor plays a pivotal role in the prostate. Its primary function is to provide
responsive gene products for differentiation and growth, but under abnormal conditions it …

The steroid hormone signaling axis is thought to play a central role in initiation and
progression of many hormonally regulated epithelial tumors. It is unclear whether all cancer …

Recently identified androgen receptor (AR) coactivators were used in this study to determine
whether the specificity of sex hormones and antiandrogens could be modulated at the …