Microneedle (MN) patches consisting of miniature needles have emerged as a promising
tool to perforate the stratum corneum and translocate biomolecules into the dermis in a …

Microneedles are one of the most prominent approaches capable of physically disrupting
the stratum corneum without devastating the deeper tissues to deliver both small molecules …

Drug delivery is often limited by the need to cross a barrier to gain access to target tissues. In
the case of skin, the main barrier is the skinLs outer layer of stratum corneum, which …

Human skin is a multilayered physiochemical barrier protecting the human body. The
stratum corneum (SC) is the outermost keratinized layer of skin through which only …

The growing demand for patient-compliance therapies in recent years has led to the
development of transdermal drug delivery, which possesses several advantages compared …

Microneedles (MN s) are micron‐sized, minimally invasive devices that breach the
outermost layer of the skin, the stratum corneum (SC), creating transient, aqueous pores in …

Dissolvable transdermal microneedles (μND) are promising micro-devices used to transport
a wide selection of active compounds into the skin. To provide an effective therapeutic …

The intrinsic properties of therapeutic proteins generally present a major impediment for
transdermal delivery, including their relatively large molecule size and susceptibility to …

Polymeric microneedle (MN) systems are interesting transdermal drug delivery systems
because of their controlled drug delivery, tunable properties, and ease of patient self …

The success of protein, peptide and antibody based therapies is evident-the
biopharmaceuticals market is predicted to reach $388 billion by 2024 [1], and more than half …