At first glance the destruction of a target cell by a killer cell seems to be a simple endeavor. A
closer look, however, reveals the complex mechanisms underlying this task. Killer cells are …

The study of the mechanisms by which cytotoxic T lymphocytes and natural killer cells kill
their targets has recently undergone an intensive surge of research activity. The renewed …

Lymphocyte-mediated cell lysis represents an important immunologic effector mechanism
involved in defense against viral infections, allograft rejection, and tumor surveillance …

In this review, we will describe our recent studies on lymphocyte cytotoxicity using a
molecular approach to the understanding of cytotoxic lymphocyte function. However, before …

. A. cytolytic effectorcell of the immune system recognizes and lyses cells carrying non-self-
epitopes, such as virus-infected cells, tumor cells, or grafted tissues [for reviews, see Berke …

The lysis of target cells attacked by cytotoxic T cells appears to be caused by two possibly
related phenomena, namely the formation of transmembrane pores in the target cell's …

Both branches, humoral and cellular, of the immune response have specialized
mechanisms to lyse tumor cells, virus-infected cells and other targets. The effector …

A major task of the immune system is to defend the body against transformed cells, cells
infected by viruses, and other foreign invaders, including bacteria and other …

Cell mediated immunity manifests itself in many responses, as diverse as skin contact
hypersensitivity, responses to viral infections, autoimmune disease, tissue allograft and …

Immune reactivity against malignant cells is well-documented for a number of lymphoid cell
types (1). The foremost features of anti-timor immune effector cells appears to be their …