Mitochondrial dysfunction in skeletal muscle has been suggested to underlie the
development of insulin resistance and type 2 diabetes mellitus. Reduced mitochondrial …

The precise cause of insulin resistance and type 2 diabetes is unknown. However, there is a
strong association between insulin resistance and lipid accumulation—and, in particular …

The prevalence of type 2 diabetes mellitus (DM2) is increasing precipitously as a
consequence of the aging population and obesity epidemic. Type 2 diabetes mellitus is …

The mechanism (s) behind the decreased ability of insulin to facilitate glucose uptake in
insulin sensitive tissues as seen in type 2 diabetes is not resolved. With the rapidly …

Insulin resistance in skeletal muscle is a major hallmark of type 2 diabetes mellitus (T2D)
and obesity that is characterized by impaired insulin-mediated glucose transport and …

Mitochondrial dysfunction has been associated with insulin resistance, obesity and diabetes.
Hyperinsulinaemia and hyperlipidaemia are hallmarks of the insulin-resistant state. We …

As a major site of glucose uptake following a meal, skeletal muscle has an important role in
whole-body glucose metabolism. Evidence in humans and animal models of insulin …

Mitochondrial dysfunction in skeletal muscle has been implicated in the development of type
2 diabetes. However, whether these changes are a cause or a consequence of insulin …

A reduced capacity for mitochondrial fatty acid oxidation in skeletal muscle has been
proposed as a major factor leading to the accumulation of intramuscular lipids and their …

Insulin resistance is a key defect associated with obesity and type-2 diabetes. The precise
factors that lead to insulin resistance have not been elucidated fully, but there is a strong …