The discovery of causative genetic mutations in affected family members has historically
dominated our understanding of neurodegenerative diseases such as Alzheimer's disease …

The successful discovery of genes that cause rare monogenic disorders has dominated our
understanding of the genetic basis of neurodegenerative disease. The emergence of robust …

Background Genome-wide association studies (GWAS) have indicated moderate genetic
overlap between Alzheimer's disease (AD) and related dementias (ADRD), Parkinson's …

Genetic factors are central to the etiology of neurodegeneration, both as monogenic causes
of heritable disease and as modifiers of susceptibility to complex, sporadic disorders. Over …

Alzheimer's disease (AD) is the most common neurodegenerative disease and, owing to its
increasing prevalence, represents one of the leading public health problems in aging …

Previous genome-wide association studies (GWAS), conducted by our group and others,
have identified loci that harbor risk variants for neurodegenerative diseases, including …

Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis are pressing health concerns in modern societies for which …

Overlapping symptoms and co-pathologies are common in closely related
neurodegenerative diseases (NDDs). Investigating genetic risk variants across these NDDs …

The genetics of Alzheimer disease (AD) to date support an age-dependent dichotomous
model whereby earlier age of disease onset (< 60 years) is explained by 3 fully penetrant …

Several common psychiatric and neurodegenerative diseases share epidemiologic risk;
however, whether they share pathophysiology is unclear and is the focus of our …