IL-2-dependent proliferation of murine T cells requires expression of both the p55 and p70 subunits of the IL-2 receptor.
DL Jankovic, A Rebollo, A Kumar, M Gibert… - Journal of immunology …, 1990 - journals.aai.org
An IL-4-dependent T cell clone (LD8) was isolated from the murine IL-2-dependent cytotoxic
T cell line C30. 1. This clone has lost the capacity to proliferate in response to IL-2 after long …
T cell line C30. 1. This clone has lost the capacity to proliferate in response to IL-2 after long …
Activation by IL-2, but not IL-4, up-regulates the expression of the p55 subunit of the IL-2 receptor on IL-2-and IL-4-dependent T cell lines.
DL Jankovic, M Gibert, D Baran, J Ohara… - … (Baltimore, Md.: 1950 …, 1989 - journals.aai.org
We have investigated the effects of IL-2 and IL-4 on different parameters of T cell activation
using three T cell lines. The Th cell line L14 and the cytotoxic T cell line C30. 1, both grown …
using three T cell lines. The Th cell line L14 and the cytotoxic T cell line C30. 1, both grown …
Intermediate-and high-affinity interleukin-2 receptors expressed in an IL-4-dependent T-cell line induce different signals.
A Rebollo, A Silva - Immunology, 1993 - ncbi.nlm.nih.gov
In order to understand the respective roles of IL-2R alpha and IL-2R beta subunits in
transmission of the interleukin-2 (IL-2)-mediated growth signals, we have established two IL …
transmission of the interleukin-2 (IL-2)-mediated growth signals, we have established two IL …
IL-4 induces IL-2 receptor p75 beta-chain gene expression and IL-2-dependent proliferation in mouse T lymphocytes.
LS Casey, AH Lichtman, M Boothby - Journal of immunology …, 1992 - journals.aai.org
T and B cells exhibit complex responses to the combination of IL-2 and IL-4, each of which
can act as a growth or differentiation factor for lymphocytes under certain circumstances. To …
can act as a growth or differentiation factor for lymphocytes under certain circumstances. To …
The role of IL-2 interaction with p75 and p55 receptor molecules in the stimulation of cell proliferation
GR Perkins, CL Flemming, D Kabat… - International …, 1993 - academic.oup.com
This report addresses the role of individual IL-2 binding proteins of the IL-2 receptor In the
stimulation of cell proliferation by IL-2. Murine IL-3-dependent cell lines were established …
stimulation of cell proliferation by IL-2. Murine IL-3-dependent cell lines were established …
Differential expression of the IL-2 receptor subunits, p55 and p75 on various populations of primary peripheral blood mononuclear cells.
Y Ohashi, T Takeshita, K Nagata, S Mori… - Journal of immunology …, 1989 - journals.aai.org
Unstimulated PBL were examined for expression of IL-2R subunits, IL-2Rp55 and IL-2Rp75,
by two-color flow cytometric analyses using mAb. NKH-1+ non-T non-B cells expressed IL …
by two-color flow cytometric analyses using mAb. NKH-1+ non-T non-B cells expressed IL …
Interleukin-4 downregulates the p70 chain of the IL-2 receptor on peripheral blood mononuclear cells
C Lindqvist, EL Nihlmark, T Nordström… - Cellular immunology, 1991 - Elsevier
Data that support a differential regulation of the interleukin-2 receptor (IL-2R) α-(p55 or Tac)
and β-chain (p70) expression by IL-4 are presented. Cytofluorometric analysis performed on …
and β-chain (p70) expression by IL-4 are presented. Cytofluorometric analysis performed on …
Internalization of interleukin 2 (IL-2) by high affinity IL-2 receptors is required for the growth of IL-2-dependent T cell lines.
A Kumar, JL Moreau, M Gibert… - Journal of immunology …, 1987 - journals.aai.org
During the growth of interleukin 2 (IL-2)-dependent T cells IL-2 binding is followed by
internalization of the complex between IL-2 and the high affinity IL-2 receptor (HA-IL-2R) …
internalization of the complex between IL-2 and the high affinity IL-2 receptor (HA-IL-2R) …
High-affinity and intermediate-affinity forms of the human interleukin 2 receptor, expressed in an interleukin 9-dependent murine T cell line, deliver proliferative signals …
C Pitton, A Rebollo, J Van Snick, J Thèze, A Garcia - Cytokine, 1993 - Elsevier
Although several reports have claimed that the p70 IL-2R per se transduces a growth signal
in lymphoid and non-lymphoid systems, there is no convincing evidence for this in lymphoid …
in lymphoid and non-lymphoid systems, there is no convincing evidence for this in lymphoid …
Reconstitution of a functional interleukin 2 receptor in a nonlymphoid cell.
LA Rubin, GS Hoekzema, DL Nelson… - … (Baltimore, Md.: 1950 …, 1987 - journals.aai.org
The maintenance of T lymphocytes which are important effectors of immune responses
requires the T cell growth factor, interleukin 2 (IL-2). The binding of IL-2 to specific cell …
requires the T cell growth factor, interleukin 2 (IL-2). The binding of IL-2 to specific cell …