Th17 cells in autoimmune demyelinating disease

BM Segal - Seminars in immunopathology, 2010 - Springer
Recently published studies in multiple sclerosis (MS) and experimental autoimmune
encephalomyelitis (EAE) have demonstrated an association between the development of …

IL-17 and related cytokines involved in the pathology and immunotherapy of multiple sclerosis: current and future developments

DW Luchtman, E Ellwardt, C Larochelle… - Cytokine & growth factor …, 2014 - Elsevier
Multiple sclerosis (MS), an autoimmune neurological disorder, is driven by self-reactive T
helper (Th) cells. Research on the role of Th17 lymphocytes in MS pathogenesis has made …

The role of TH17 cells in multiple sclerosis: Therapeutic implications

T Moser, K Akgün, U Proschmann, J Sellner… - Autoimmunity …, 2020 - Elsevier
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) where immunopathology is thought to be mediated by myelin-reactive CD4+ T …

IL-17A and multiple sclerosis: signaling pathways, producing cells and target cells in the central nervous system

F Kolbinger, C Huppertz, A Mir… - Current Drug …, 2016 - ingentaconnect.com
Multiple sclerosis (MS) is an immune mediated demyelinating disease of the central nervous
system (CNS). The importance of immune cells to MS pathology is supported by clinical data …

TH17 cytokines in autoimmune neuro-inflammation

B Becher, BM Segal - Current opinion in immunology, 2011 - Elsevier
It has been firmly established that IL-23 polarized TH17 cells are potent effectors in the
pathogenesis of experimental autoimmune encephalitomyelitis (EAE). However, the relative …

IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis

S Serada, M Fujimoto, M Mihara… - Proceedings of the …, 2008 - National Acad Sciences
The development of Th17 cells is a key event in the pathogenesis of experimental
autoimmune encephalomyelitis (EAE), a murine model of human multiple sclerosis (MS) …

Current views on the roles of Th1 and Th17 cells in experimental autoimmune encephalomyelitis

M El-behi, A Rostami, B Ciric - Journal of Neuroimmune Pharmacology, 2010 - Springer
Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis
(EAE), are autoimmune demyelinating diseases of the central nervous system (CNS) …

Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis

V Brucklacher-Waldert, K Stuerner, M Kolster… - Brain, 2009 - academic.oup.com
Multiple sclerosis is a T cell-mediated demyelinating disease of the central nervous system.
Interleukin-17-producing T helper cells, named Th17 cells, represent a novel CD4+ T cell …

Th17 cells, γδ T cells and their interplay in EAE and multiple sclerosis

AM McGinley, SC Edwards, M Raverdeau… - Journal of …, 2018 - Elsevier
Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis
(MS) that shares many features with the human disease. This review will focus on the role of …

The interleukin (IL)-23/T helper (Th) 17 axis in experimental autoimmune encephalomyelitis and multiple sclerosis

M Hiltensperger, T Korn - Cold Spring …, 2018 - perspectivesinmedicine.cshlp.org
T helper (Th) 17 cells are responsible for host defense against fungi and certain extracellular
bacteria but have also been reported to play a role in a variety of autoimmune diseases …