Receptor antagonists can be classified as neutral antagonists or antagonists with inverse
agonist activity based on their effectiveness to reduce the spontaneous agonist-independent …

The allosteric enhancer PD 81,723, a 2-amino-3-benzoylthiophene derivative, has been
shown to potentiate agonist binding to A1 adenosine receptors (A1AdoRs) and to enhance …

To examine the importance of the nine native cysteine residues in the human A1 adenosine
receptor, each cysteine was individually mutated to both serine and alanine. Saturation …

To examine possible species differences in pharmacology, rat adenosine A2A receptors
were studied in PC12 (pheochromocytoma) cells, and human receptors in Chinese hamster …

To provide new insights into the regions of the human A 1 adenosine receptor (A 1 AR)
involved in ligand binding, a series of chimeric human A 1 and rat A 1 adenosine receptors …

The objective of this study was to create constitutively active mutant human A3 adenosine
receptors (ARs) using single amino acid replacements, based on findings from other G …

The A 2a adenosine receptor, a member of the G protein-coupled receptor family, is
important in the regulation of dopaminergic pathways of the brain and in platelet and …

Using receptor-selective agonists and antagonists, the possible presence of both A2a and
A2b adenosine receptor subtypes coupled to activation of adenylyl cyclase was investigated …

Mutagenesis of the human A3 adenosine receptor (AR) suggested that certain amino acid
residues contributed differently to ligand binding and activation processes. Here we …

5 '-(Alkylthio)-substituted analogues of N 6-benzyl-and N 6-(3-iodobenzyl) adenosine were
synthesized in 37− 61% overall yields. The affinities of these compounds for the adenosine …