Bolus therapy with 3% hypertonic saline or 0.9% saline in emergency department patients with suspected sepsis: a pilot randomised controlled trial
Objective and design Hypertonic saline administered during fluid resuscitation may mitigate
endothelial glycocalyx (EG) shedding and inflammation. The objective of this pilot …
endothelial glycocalyx (EG) shedding and inflammation. The objective of this pilot …
Effect of intravenous fluid volume on biomarkers of endothelial glycocalyx shedding and inflammation during initial resuscitation of sepsis
Purpose To investigate the effect of IV fluid resuscitation on endothelial glycocalyx (EG)
shedding and activation of the vascular endothelium and inflammation. Materials and …
shedding and activation of the vascular endothelium and inflammation. Materials and …
The effects of a limited infusion rate of fluid in the early resuscitation of sepsis on glycocalyx shedding measured by plasma syndecan-1: a randomized controlled trial
J Saoraya, L Wongsamita, N Srisawat… - Journal of Intensive …, 2021 - Springer
Background Aggressive fluid administration is recommended in the resuscitation of septic
patients. However, the delivery of a rapid fluid bolus might cause harm by inducing …
patients. However, the delivery of a rapid fluid bolus might cause harm by inducing …
Hypertonic saline in human sepsis: a systematic review of randomized controlled trials
D Orbegozo, JL Vincent, J Creteur, F Su - Anesthesia & Analgesia, 2019 - journals.lww.com
The role of hypertonic saline in sepsis remains unclear because clinical data are limited and
the balance between beneficial and adverse effects is not well defined. In this systematic …
the balance between beneficial and adverse effects is not well defined. In this systematic …
No association between intravenous fluid volume and endothelial glycocalyx shedding in patients undergoing resuscitation for sepsis in the emergency department
Endothelial glycocalyx (EG) shedding is associated with septic shock and described
following intravenous (IV) fluid administration. To investigate the possible impact of IV fluids …
following intravenous (IV) fluid administration. To investigate the possible impact of IV fluids …
Fluid resuscitation and markers of glycocalyx degradation in severe sepsis
X Wu, Z Hu, H Yuan, L Chen, Y Li, C Zhao - Open Medicine, 2017 - degruyter.com
Background The aim of this study was to determine the relationship between fluid
resuscitation and glycocalyx degradation in severe sepsis. Methodology 15 post …
resuscitation and glycocalyx degradation in severe sepsis. Methodology 15 post …
Endothelial glycocalyx biomarkers increase in patients with infection during Emergency Department treatment
L Smart, SPJ Macdonald, S Burrows, E Bosio… - Journal of critical …, 2017 - Elsevier
Purpose Endothelial glycocalyx (EG) shedding may promote organ failure in sepsis. This
study describes temporal changes in EG biomarkers from Emergency Department (ED) …
study describes temporal changes in EG biomarkers from Emergency Department (ED) …
Hypertonic saline resuscitation in sepsis
CE Wade - Critical Care, 2002 - Springer
The review by Oliveira and colleagues on the subject of hypertonic saline resuscitation in
sepsis (included in the present issue) suggests possible benefits for hypertonic saline. There …
sepsis (included in the present issue) suggests possible benefits for hypertonic saline. There …
Protocol for a pilot randomized controlled trial comparing plasma with balanced crystalloid resuscitation in surgical and trauma patients with septic shock
Background Septic shock is a public health problem with high mortality. There remains a
knowledge gap regarding the optimal resuscitation fluid to improve clinical outcomes, and …
knowledge gap regarding the optimal resuscitation fluid to improve clinical outcomes, and …
Acetate Ringer's Solution versus Normal Saline Solution in Sepsis: A Randomized, Controlled Trial
J Zhang, F Liu, Z Wu, J Jiang, B Wang, Y Qian, J Suo… - Shock, 2023 - journals.lww.com
Background Slaine solution (NSS) and Ringer's acetate solution (RAS) are commonly given
to critical ill patients as a fundamental fluid therapy. However, the effect of RAS and NSS on …
to critical ill patients as a fundamental fluid therapy. However, the effect of RAS and NSS on …
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