A better understanding of cytokine biology over the last two decades has allowed the
successful development of cytokine inhibitors against tumour necrosis factor and interleukin …

Cytokines are immune mediators that play an important role in the pathogenesis of
rheumatoid arthritis (RA), an autoimmune disease that targets the synovial joints. The …

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterised by chronic joint
inflammation and destruction. Interleukin (IL)-17 is a T cell cytokine expressed in the …

Rheumatoid arthritis (RA) is a chronic inflammatory disease leading to joint destruction.
Cytokines play a key role in its pathogenesis. They contribute to the induction and …

Interleukin (IL)-17 is a T-cell-derived cytokine that is expressed in the synovium of patients
with arthritis. IL-17 contributes to the pathogenesis of arthritis, and demonstrates additive or …

The favorable clinical results obtained with tumor necrosis factor(TNF) and interleukin-1 (IL-
1) inhibitors may suggest that the story of the contribution of cytokines to arthritis is almost …

A large number of cytokines are active in the joints of patients with rheumatoid arthritis (RA).
It is now clear that these cytokines play a fundamental role in the processes that cause …

The IL-12 family members, IL-12, IL-23, IL-27 and IL-35, are heterodimeric cytokines that
share subunits and have important roles in autoimmunity. As well as their structural …

Interleukin (IL) 10 looms as a highly promising treatment for rheumatoid arthritis (RA)
because of its capacity to inhibit cellular immunity and deactivate macrophages. In RA …

More than any other cytokine family, the 11 members of the IL-1 family are associated with
innate immune responses, which occur in acute inflammation and chronic inflammatory …