Expression of SARS-CoV-2 entry molecules ACE2 and TMPRSS2 in the gut of patients with IBD
JF Burgueno, A Reich, H Hazime… - Inflammatory bowel …, 2020 - academic.oup.com
Background Patients with inflammatory bowel disease (IBD) have intestinal inflammation
and are treated with immune-modulating medications. In the face of the coronavirus disease …
and are treated with immune-modulating medications. In the face of the coronavirus disease …
Age, inflammation, and disease location are critical determinants of intestinal expression of SARS-CoV-2 receptor ACE2 and TMPRSS2 in inflammatory bowel …
Methods We compared RNA expression of ACE2 and TMPRSS2 in blood (paired-end
sequencing), ileal, and colonic mucosal biopsies (microarray) from 138 patients with …
sequencing), ileal, and colonic mucosal biopsies (microarray) from 138 patients with …
Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2–related disease
M Suárez-Fariñas, M Tokuyama, G Wei, R Huang… - Gastroenterology, 2021 - Elsevier
Background and Aims The presence of gastrointestinal symptoms and high levels of viral
RNA in the stool suggest active severe acute respiratory syndrome coronavirus 2 (SARS …
RNA in the stool suggest active severe acute respiratory syndrome coronavirus 2 (SARS …
Altered intestinal ACE2 levels are associated with inflammation, severe disease, and response to anti-cytokine therapy in inflammatory bowel disease
AA Potdar, S Dube, T Naito, K Li, G Botwin… - Gastroenterology, 2021 - Elsevier
Background And Aims The host receptor for severe acute respiratory syndrome coronavirus
2, angiotensin-converting enzyme 2 (ACE2), is highly expressed in small bowel (SB). Our …
2, angiotensin-converting enzyme 2 (ACE2), is highly expressed in small bowel (SB). Our …
SARS-CoV-2 receptor ACE2 gene expression in small intestine correlates with age
RN Vuille-dit-Bille, KW Liechty, F Verrey… - Amino acids, 2020 - Springer
Gastrointestinal symptoms are common in COVID-19 patients, especially in younger
patients. Our hypothesis was that intestinal SARS-CoV-2 receptor ACE2 expression …
patients. Our hypothesis was that intestinal SARS-CoV-2 receptor ACE2 expression …
Robust and persistent SARS-CoV-2 infection in the human intestinal brush border expressing cells
Studies on patients with the coronavirus disease-2019 (COVID-19) have implicated that the
gastrointestinal (GI) tract is a major site of severe acute respiratory syndrome coronavirus 2 …
gastrointestinal (GI) tract is a major site of severe acute respiratory syndrome coronavirus 2 …
Diarrhea during COVID-19 infection: pathogenesis, epidemiology, prevention, and management
F D'amico, DC Baumgart, S Danese… - Clinical …, 2020 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/COVID-19) pandemic is
a worldwide emergency. An increasing number of diarrhea cases is reported. Here we …
a worldwide emergency. An increasing number of diarrhea cases is reported. Here we …
Digestive system is a potential route of COVID-19: an analysis of single-cell coexpression pattern of key proteins in viral entry process
H Zhang, Z Kang, H Gong, D Xu, J Wang, Z Li, Z Li… - Gut, 2020 - gut.bmj.com
Objective Since December 2019, a newly identified coronavirus (severe acute respiratory
syndrome coronavirus (SARS-CoV-2)) has caused outbreaks of pneumonia in Wuhan …
syndrome coronavirus (SARS-CoV-2)) has caused outbreaks of pneumonia in Wuhan …
[HTML][HTML] Pathophysiological mechanisms underlying gastrointestinal symptoms in patients with COVID-19
Gastrointestinal (GI) symptoms, such as diarrhea, abdominal pain, vomiting, and anorexia,
are frequently observed in patients with coronavirus disease 2019 (COVID-19). However …
are frequently observed in patients with coronavirus disease 2019 (COVID-19). However …
Diarrhoea may be underestimated: a missing link in 2019 novel coronavirus
A series of pneumonia cases caused by 2019 novel coronavirus (2019-nCoV, also named
COVID-19) are being reported globally. Based on recent publications, 1–3 the most common …
COVID-19) are being reported globally. Based on recent publications, 1–3 the most common …