[HTML][HTML] Application of cancer genomics to solve unmet clinical needs

SH Lee, SH Sim, JY Kim, SJ Cha, A Song - Genomics & informatics, 2013 - ncbi.nlm.nih.gov
The large amount of data on cancer genome research has contributed to our understanding
of cancer biology. Indeed, the genomics approach has a strong advantage for analyzing …

Methods and resources to access mutation-dependent effects on cancer drug treatment

H Yao, Q Liang, X Qian, J Wang… - Briefings in …, 2020 - academic.oup.com
In clinical cancer treatment, genomic alterations would often affect the response of patients
to anticancer drugs. Studies have shown that molecular features of tumors could be …

[HTML][HTML] Integrative Bioinformatics approaches to therapeutic gene target selection in various cancers for Nitroglycerin

J Chinnappan, A Ramu, VR V - Scientific Reports, 2021 - nature.com
Integrative Bioinformatics analysis helps to explore various mechanisms of Nitroglycerin
activity in different types of cancers and help predict target genes through which …

[图书][B] Cancer genomics: molecular classification, prognosis and response prediction

U Pfeffer - 2013 - books.google.com
The combination of molecular biology, engineering and bioinformatics has revolutionized
our understanding of cancer revealing a tight correlation of the molecular characteristics of …

Molecular Oncology Principles and Recent Advances

J Camacho - 2012 - books.google.com
Cancer is one of the major causes of death worldwide. Despite hundreds of clinical trials
currently in progress for cancer patients, the success rate is still very low. Understanding the …

[HTML][HTML] Using machine learning algorithms to identify genes essential for cell survival

S Philips, HY Wu, L Li - BMC bioinformatics, 2017 - Springer
Background With the explosion of data comes a proportional opportunity to identify novel
knowledge with the potential for application in targeted therapies. In spite of this huge …

[HTML][HTML] A unified platform enabling biomarker ranking and validation for 1562 drugs using transcriptomic data of 1250 cancer cell lines

JT Fekete, B Győrffy - Computational and Structural Biotechnology Journal, 2022 - Elsevier
Intro In vitro cell line models provide a valuable resource to investigate compounds useful in
the systemic chemotherapy of cancer. However, the due to the dispersal of the data into …

[HTML][HTML] Using functional signatures to identify repositioned drugs for breast, myelogenous leukemia and prostate cancer

D Shigemizu, Z Hu, JH Hung, CL Huang… - PLoS computational …, 2012 - journals.plos.org
The cost and time to develop a drug continues to be a major barrier to widespread
distribution of medication. Although the genomic revolution appears to have had little impact …

[HTML][HTML] Cutting-edge ai technologies meet precision medicine to improve cancer care

PC Lin, YS Tsai, YM Yeh, MR Shen - Biomolecules, 2022 - mdpi.com
To provide precision medicine for better cancer care, researchers must work on clinical
patient data, such as electronic medical records, physiological measurements, biochemistry …

[PDF][PDF] Application of genomics and proteomics in drug target discovery

HM Zhang, ZR Nan, GQ Hui, XH Liu, Y Sun - Genet Mol Res, 2014 - geneticsmr.com
Gene medicine is making breakthroughs in health questions that have baffled humanity for
centuries. To understand and utilize gene medicine, it is necessary to realize its action …