The dysregulation of the insulin‐glucose axis represents the crucial event in insulin
resistance syndrome. Insulin resistance increases atherogenesis and atherosclerotic plaque …

Th e E dwin Bierman Award Lecture is presented in honor of the memory of Edwin L.
Bierman, MD, an exemplary scientist, mentor, and leader in the field of diabetes, obesity …

With a positive caloric balance, adipocytes undergo excessive hypertrophy, which causes
adipocyte dysfunction, as well as adipose tissue endocrine and immune responses. A …

Obesity-induced low-grade inflammation (metaflammation) impairs insulin receptor
signaling. This has been implicated in the development of insulin resistance. Insulin …

Insulin resistance is an important contributor to the pathogenesis of T2D and obesity is a risk
factor for its development. It has been demonstrated that these obesity-related metabolic …

Insulin resistance and inflammation are recognized as important links between obesity and
cardiovascular disease (CVD). Plasma free fatty acids (FFA), either released from the …

Insulin resistance (IR) plays a key role in the pathophysiology of obesity-related diseases
such as type 2 diabetes and nonalcoholic fatty liver disease. It has been demonstrated that …

Obesity is a growing problem in modern society and medicine. It closely associates with
metabolic disorders such as type 2 diabetes mellitus (T2DM) and hepatic and …

Insulin resistance has been recognized as an inflammatory disease based on the scientific
evidence collected over the last decade. Inflammatory markers like CRP, PAI-1, IL-6 are …

The insulin resistance syndrome, otherwise known as the metabolic syndrome, describes a
cluster of cardiovascular and metabolic abnormalities, which are strongly associated with …