Activation of hepatic stellate cells in response to chronic inflammation represents a crucial
step in the development of liver fibrosis. However, the molecules involved in the interaction …

Chemokine receptors mediate migration of immune cells into the liver, thereby promoting
liver inflammation. C‐C motif chemokine receptor (CCR) 9+ macrophages are crucial in the …

Chronic liver injury promotes hepatic inflammation, representing a prerequisite for organ
fibrosis. We hypothesized a contribution of chemokine receptor CCR6 and its ligand …

Chemokines and chemokine receptors contribute to the migration of hepatic stellate cells
(HSCs) and Kupffer cells, two key cell types in fibrogenesis. Here, we investigate the role of …

Hepatic fibrosis develops as a response to chronic liver injury and almost exclusively occurs
in a proinflammatory environment. However, the role of inflammatory mediators in fibrogenic …

Chemokines, such as CXCL10, promote hepatic inflammation in chronic or acute liver injury
through recruitment of leukocytes to the liver parenchyma. The CXCL10 receptor CXCR3 …

Inflammation has been shown to induce the progression of fibrosis in response to liver
injury. Among inflammatory cells, macrophages and lymphocytes play major roles in both …

Chemokines critically control the infiltration of immune cells upon liver injury, thereby
promoting hepatic inflammation and fibrosis. The chemokine receptor CCR8 can affect …

Liver fibrosis is a major cause of morbidity and mortality worldwide. Platelets are involved in
liver damage, but the underlying molecular mechanisms remain elusive. Here, we …

Background Nonalcoholic fatty liver disease (NAFLD) is a prevalent complication of extreme
obesity. Loading of the liver with fat can progress to inflammation and fibrosis including …