Targeting stem cells in the realm of drug-resistant breast cancer

P Dey, M Rathod, A De - Breast Cancer: Targets and Therapy, 2019 - Taylor & Francis
Since its first documentation, breast cancer (BC) has been a conundrum that ails millions of
women every year. This cancer has been well studied by researchers all over the world …

Targeting breast cancer stem cells to overcome treatment resistance

S Palomeras, S Ruiz-Martínez, T Puig - Molecules, 2018 - mdpi.com
Despite advances in breast cancer diagnosis and treatment, many patients still fail therapy,
resulting in disease progression, recurrence, and reduced overall survival. Historically …

[HTML][HTML] Breast cancer stem-like cells in drug resistance: a review of mechanisms and novel therapeutic strategies to overcome drug resistance

T Saha, KE Lukong - Frontiers in oncology, 2022 - frontiersin.org
Breast cancer is the most frequent type of malignancy in women worldwide, and drug
resistance to the available systemic therapies remains a major challenge. At the molecular …

Cancer stem cell in breast cancer therapeutic resistance

X Bai, J Ni, J Beretov, P Graham, Y Li - Cancer treatment reviews, 2018 - Elsevier
Abstract Development of therapeutic resistance and metastasis is a major challenge with
current breast cancer (BC) therapy. Mounting evidence suggests that a subpopulation of …

[HTML][HTML] Novel and alternative targets against breast cancer stemness to combat chemoresistance

S Sridharan, CM Howard, AMC Tilley… - Frontiers in …, 2019 - frontiersin.org
Breast cancer stem cells (BCSCs) play a vital role in tumor progression and metastasis.
They are heterogeneous and inherently radio-and chemoresistant. They have the ability to …

The breast cancer stem cells traits and drug resistance

Q Zheng, M Zhang, F Zhou, L Zhang… - Frontiers in …, 2021 - frontiersin.org
Drug resistance is a major challenge in breast cancer (BC) treatment at present.
Accumulating studies indicate that breast cancer stem cells (BCSCs) are responsible for the …

Breast cancer stem cells as drivers of tumor chemoresistance, dormancy and relapse: new challenges and therapeutic opportunities

ML De Angelis, F Francescangeli, A Zeuner - Cancers, 2019 - mdpi.com
Breast cancer is the most frequent cancer among women worldwide. Therapeutic strategies
to prevent or treat metastatic disease are still inadequate although great progress has been …

[HTML][HTML] Trailblazing perspectives on targeting breast cancer stem cells

J Li, D Qi, TC Hsieh, JH Huang, JM Wu, E Wu - Pharmacology & …, 2021 - Elsevier
Breast cancer (BCa) is one of the most prevalent malignant tumors affecting women's health
worldwide. The recurrence and metastasis of BCa have made it a long-standing challenge …

[HTML][HTML] Targeted therapies in breast cancer: New challenges to fight against resistance

V Masoud, G Pagès - World journal of clinical oncology, 2017 - ncbi.nlm.nih.gov
Breast cancer is the most common type of cancer found in women and today represents a
significant challenge to public health. With the latest breakthroughs in molecular biology and …

Molecular biology of breast cancer stem cells: potential clinical applications

NP Nguyen, FS Almeida, A Chi, LM Nguyen… - Cancer treatment …, 2010 - Elsevier
Breast cancer stem cells (CSC) have been postulated recently as responsible for failure of
breast cancer treatment. The purpose of this study is to review breast CSCs molecular …