Genetic factors explain a major fraction of the 50% lower lipoprotein (a) concentrations in Finns
G Erhart, C Lamina, T Lehtimäki… - … , and vascular biology, 2018 - Am Heart Assoc
Objective—Lp (a)(lipoprotein (a)) concentrations are widely genetically determined by the
LPA isoforms and show 5-fold interpopulation differences. Two-to 3-fold differences have …
LPA isoforms and show 5-fold interpopulation differences. Two-to 3-fold differences have …
[HTML][HTML] Long-term tracking and population characteristics of lipoprotein (a) in the Cardiovascular Risk in Young Finns Study
O Raitakari, A Kivelä, K Pahkala, S Rovio, J Mykkänen… - Atherosclerosis, 2022 - Elsevier
Background and aims Lipoprotein (a)(Lp (a)) is a causal risk factor for cardiovascular
diseases and its levels are under strict genetic control. Therefore, it is hypothesized that the …
diseases and its levels are under strict genetic control. Therefore, it is hypothesized that the …
Genetic control of lipoprotein (a) concentrations is different in Africans and Caucasians
M Scholz, HG Kraft, A Lingenhel, R Delport… - European Journal of …, 1999 - nature.com
Abstract Lipoprotein (a)(Lp (a)) represents a quantitative trait in human plasma associated
with atherothrombotic disease. Large variation in the distribution of Lp (a) concentrations …
with atherothrombotic disease. Large variation in the distribution of Lp (a) concentrations …
Relationship between plasma lipoprotein (a), apolipoprotein (a) phenotypes, and other coronary heart disease risk factors in a Melbourne South Asian population
ZW Xiong, ML Wahlqvist, TI Ibiebele, BM Biegler… - Clinical …, 2004 - Elsevier
Background: High plasma lipoprotein (a)[Lp (a)] level is a strong and important risk factor for
cardiovascular disease (CVD). Small-sized apolipoprotein (a)[apo (a)] isoforms (F, B, S1 …
cardiovascular disease (CVD). Small-sized apolipoprotein (a)[apo (a)] isoforms (F, B, S1 …
[HTML][HTML] Genetics of the Lp (a)/apo (a) system in an autochthonous Black African population from the Gabon
K Schmidt, HG Kraft, W Parson… - European journal of human …, 2006 - nature.com
Abstract Plasma lipoprotein (a)(Lp (a)) is a quantitative trait associated with atherothrombotic
disease in European and Asian populations. Lp (a) concentrations vary widely within and …
disease in European and Asian populations. Lp (a) concentrations vary widely within and …
Significant impact of the+ 93 C/T polymorphism in the apolipoprotein (a) gene on Lp (a) concentrations in Africans but not in Caucasians: confounding effect of linkage …
HG Kraft, M Windegger, HJ Menzel… - Human molecular …, 1998 - academic.oup.com
Abstract Lipoprotein (a)[Lp (a)] is a quantitative genetic trait in human plasma associated
with atherothrombotic disease. The major determinant of Lp (a) concentration is the …
with atherothrombotic disease. The major determinant of Lp (a) concentration is the …
Mechanisms of lipoprotein (a) pathogenicity: prothrombotic, proatherosclerotic, or both?
JD Spence, M Koschinsky - Arteriosclerosis, Thrombosis, and …, 2012 - Am Heart Assoc
(Arterioscler Thromb Vasc Biol. 2012; 32: 1550–1551.) angiographically, but carotid stenosis
(≥ 50%) was assessed by Doppler ultrasound, and peripheral vascular disease by …
(≥ 50%) was assessed by Doppler ultrasound, and peripheral vascular disease by …
Three single-nucleotide polymorphisms in LPA account for most of the increase in lipoprotein (a) level elevation in African Americans compared with European …
JP Chretien, J Coresh, Y Berthier-Schaad… - Journal of medical …, 2006 - jmg.bmj.com
Background: The extent which universally common or population-specific alleles can
explain between-population variations in phenotypes is unknown. The heritable coronary …
explain between-population variations in phenotypes is unknown. The heritable coronary …
Lipoprotein (a): relation to other risk factors and genetic heritability. Results from a Dutch parent-twin study
DI Boomsma, A Kaptein, HJM Kempen, JAG Leuven… - Atherosclerosis, 1993 - Elsevier
We measured plasma levels of lipoprotein (a)(Lp (a)) in a sample of 152 Dutch adolescent
mono-and dizygotic twin pairs and their parents. The distribution of Lp (a) levels was …
mono-and dizygotic twin pairs and their parents. The distribution of Lp (a) levels was …
Lipoprotein (a): genotype–phenotype relationship and impact on atherogenic risk
B Enkhmaa, E Anuurad, W Zhang, T Tran… - … syndrome and related …, 2011 - liebertpub.com
In 2010, more than 45 years after the initial discovery of lipoprotein (a)[Lp (a)] by Kare Berg,
an European Atherosclerosis Society Consensus Panel recommended screening for …
an European Atherosclerosis Society Consensus Panel recommended screening for …