Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy

Y Gong, RGJ Klein Wolterink, J Wang, GMJ Bos… - Journal of hematology & …, 2021 - Springer
Due to their efficient recognition and lysis of malignant cells, natural killer (NK) cells are
considered as specialized immune cells that can be genetically modified to obtain capable …

Chimeric antigen receptor-engineered natural killer (CAR NK) cells in cancer treatment; recent advances and future prospects

R Elahi, AH Heidary, K Hadiloo… - Stem Cell Reviews and …, 2021 - Springer
Natural Killer (NK) cells are critical members of the innate immunity lymphocytes and have a
critical role in host defense against malignant cells. Adoptive cell therapy (ACT) using …

Chimeric antigen receptor engineered natural killer cells for cancer therapy

Y Zhang, W Zhou, J Yang, J Yang, W Wang - Experimental Hematology & …, 2023 - Springer
Natural killer (NK) cells, a unique component of the innate immune system, are inherent
killers of stressed and transformed cells. Based on their potent capacity to kill cancer cells …

Chimeric antigen receptor-engineered natural killer cells for cancer immunotherapy

A Yilmaz, H Cui, MA Caligiuri, J Yu - Journal of hematology & oncology, 2020 - Springer
Natural killer (NK) cells are a critical component of the innate immune system. Chimeric
antigen receptors (CARs) re-direct NK cells toward tumor cells carrying corresponding …

Engineering natural killer cells for cancer immunotherapy

K Rezvani, R Rouce, E Liu, E Shpall - Molecular Therapy, 2017 - cell.com
The past several years have seen tremendous advances in the engineering of immune
effector cells as therapy for cancer. While chimeric antigen receptors (CARs) have been …

Chimeric antigen receptor-engineered NK cells: new weapons of cancer immunotherapy with great potential

X Wang, X Yang, X Yuan, W Wang, Y Wang - Experimental Hematology & …, 2022 - Springer
Chimeric antigen receptor (CAR)-engineered T (CAR-T) cells have obtained prominent
achievement in the clinical immunotherapy of hematological malignant tumors, leading to a …

Chimeric antigen receptor–engineered natural killer and natural killer T cells for cancer immunotherapy

D Bollino, TJ Webb - Translational Research, 2017 - Elsevier
Natural killer (NK) cells of the innate immune system and natural killer T (NKT) cells, which
have roles in both the innate and adaptive responses, are unique lymphocyte subsets that …

You have got a fast CAR: chimeric antigen receptor NK cells in cancer therapy

A Pfefferle, ND Huntington - Cancers, 2020 - mdpi.com
The clinical success stories of chimeric antigen receptor (CAR)-T cell therapy against B-cell
malignancies have contributed to immunotherapy being at the forefront of cancer therapy …

CAR-NK cells: A promising cellular immunotherapy for cancer

G Xie, H Dong, Y Liang, JD Ham, R Rizwan, J Chen - EBioMedicine, 2020 - thelancet.com
Natural Killer (NK) cells and CD8+ cytotoxic T cells are two types of immune cells that can
kill target cells through similar cytotoxic mechanisms. With the remarkable success of …

Outlook for new CAR-based therapies with a focus on CAR NK cells: what lies beyond CAR-engineered T cells in the race against cancer

M Daher, K Rezvani - Cancer discovery, 2021 - AACR
Chimeric antigen receptor (CAR) engineering of T cells has revolutionized the field of
cellular therapy for the treatment of cancer. Despite this success, autologous CAR-T cells …