The long-term consequences of neonatal endotoxin exposure on hypothalamic-pituitary-
adrenal axis (HPA) function were assessed in adult female and male Long-Evans rats. At 3 …

The present studies assessed hypothalamic‐pituitary‐adrenal (HPA) responses following
immune activation with endotoxin (ip) in three‐day old Long Evans rats. Marked plasma …

We have investigated whether exposure to Gram-negative bacterial endotoxin in early
neonatal life can alter neuroendocrine and immune regulation in adult animals. Exposure of …

Recent research in rodents has demonstrated that exposure to bacterial endotoxin during
the neonatal period alters the development of the hypothalamic-pituitary-adrenal axis …

The neonatal rat is very sensitive to the lethal effects of bacterial endotoxin. Because of the
adaptive importance of pituitary-adrenal secretions to stress, this study examined the …

Pregnancy and lactation are times of prolonged physiological changes affecting the
neuroendocrine and immunological systems. One well‐characterized change is the …

The neonatal rat shows a period of decreased responsiveness to noxious stimuli during the
first 3 weeks of life, but the nature of this impairment is still controversial. To test the …

Endotoxin is considered to be a systemic (immunological) stressor eliciting a prolonged
activation of the hypothalamo-pituitary-adrenal (HPA) axis. The HPA-axis response after an …

The responsiveness of the neonatal hypothalamus-pituitary-adrenal (HPA) axis to stress has
been thought to be impaired or diminished during the first 2 weeks of life. Although we …

This study investigated whether exposing the fetal primate to repeated episodes of maternal
stress would have long-lasting effects on the endotoxin-induced cytokine response and …