Sirt1 is a NAD+-dependent protein-modifying enzyme involved in regulating gene
expression, DNA damage repair, metabolism and survival, as well as acts as an important …

Abstract Sirtuin-1 (SIRT1) possesses apparently dual roles in regulation of tumor. Previous
reports have documented the crosstalk between SIRT1 with signal transducer and activator …

Several members of the sirtuin (SIRT) family, a highly conserved family of NAD+-dependent
enzymes, have been shown to play a critical role in both promoting and/or suppressing …

BACKGROUND: Several sirtuin family members (SIRT1‐7), which are evolutionarily
conserved NAD‐dependent deacetylases, play an important role in carcinogenesis …

Colorectal cancer (CRC) is the leading cause of cancer death; however, targets with broad
anti-CRC effects are limited. Sirtuin6 (SIRT6) is a conserved nicotinamide adenine …

Abstract SIRT1, an NAD+-dependent histone/protein deacetylase, has diverse physiological
actions. Recent studies have demonstrated that SIRT1 is overexpressed in colorectal …

SIRT1, the most conserved mammalian NAD+-dependent protein deacetylase, plays a vital
role in the regulation of metabolism, stress responses, and genome stability. However, the …

Abstract Sirtuins (SIRT1-7) are a highly conserved family of NAD+-dependent enzymes that
control the activity of histone and nonhistone regulatory proteins. SIRT1 is purposed to …

The class III deacetylase sirtuin 1 (SIRT1), a member of the sirtuin family proteins, plays a
key role in many types of cancers including colorectal cancer (CRC). Here we report that …

Sirtuin 3 (SIRT3) is the major mitochondria deacetylase and regulates ROS levels by
targeting several key proteins, such as those involved in mitochondrial function and …