Mutations in the progranulin (PGRN) gene were recently described as the cause of ubiquitin
positive frontotemporal dementia (FTD) in many families. Different frequencies of these …

Progranulin gene (PGRN) mutations cause frontotemporal lobar degeneration with ubiquitin‐
positive inclusions (FTLD‐U). Patients usually present with a frontotemporal dementia …

Frontotemporal dementia (FTD) is the second most frequent type of neurodegenerative
dementias. Mutations in the progranulin gene (GRN, PGRN) were recently identified in …

Progranulin gene (PGRN) mutations cause ubiquitin-positive frontotemporal lobar
degeneration linked to chromosome 17 (FTLDU-17). The spectrum of known mutations …

Frontotemporal lobar degeneration (FTLD) with ubiquitin-positive, tau-negative inclusions,
and linkage to chromosome 17 was recently found to be caused by mutations in the …

Abstract Ubiquitin‐positive, tau‐negative, frontotemporal dementia (FTD) is caused by null
mutations in progranulin (PGRN; HUGO gene symbol GRN), suggesting a haploinsufficiency …

Background and purpose: Mutations in the progranulin (PGRN) gene have recently been
associated with frontotemporal lobar degeneration (FTLD). The frequency of these mutations …

Mutations in progranulin (PGRN) are associated with frontotemporal dementia with or
without parkinsonism. We describe the prominent phenotypic variability within and among …

Null mutations in the progranulin gene (PGRN) were recently reported to cause tau-negative
frontotemporal dementia linked to chromosome 17. We assessed the genetic contribution of …

Abstract Objective Mutations in the Progranulin gene (PGRN) recently have been
discovered to be associated with frontotemporal dementia (FTD) linked to 17q21 without …