Angiogenesis—the formation of new blood vessels—is essential for tumour progression and
metastasis. Consequently, the modulation of tumour angiogenesis using novel agents has …

Angiogenesis, or new blood vessel growth, is essential for the growth, invasion, and
metastasis of solid tumors. The inhibition of this process, or antiangiogenesis, is a promising …

Angiogenesis is the process by which new blood vessels are formed from preexisting
microvasculature. To ensure an adequate blood supply, tumor cells release angiogenic …

Tumor angiogenesis—new drugs on the block | Nature Biotechnology Skip to main content
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A number of anti-angiogenesis drugs have been FDA-approved and are being used in
cancer treatment, and a number of other agents are in different stages of clinical …

In human patients, drugs that block tumor vessel growth are widely used to treat a variety of
cancer types. Many rigorous phase 3 clinical trials have demonstrated significant survival …

• Introduction• What can we learn from the previous failures?• Signs of hope• Another turn of
the screw: a surrogate marker, at last• Future avenues for the vascular therapy of cancer …

Angiogenesis is an essential process in tumor growth. The concept of angiogenesis, when
proposed by Folksman in 1971, had a great impact on cancer research and therapy, as the …

Deregulation of angiogenesis–the growth of new blood vessels from an existing vasculature–
is a main driving force in many severe human diseases including cancer. As such, tumor …

Since 2004, four antiangiogenic drugs have been approved for clinical use in patients with
advanced solid cancers, on the basis of their capacity to improve survival in phase III clinical …