Promises and pitfalls of anti-angiogenic therapy in clinical trials

MF McCarty, W Liu, F Fan, A Parikh, N Reimuth… - Trends in molecular …, 2003 - cell.com
A significant body of research has implicated the process of angiogenesis in the growth and
spread of tumors. Elucidation of the mechanisms of tumor angiogenesis has led to the …

[HTML][HTML] Tumor angiogenesis: Current challenges and therapeutic opportunities

FH Al-Ostoot, S Salah, HA Khamees… - Cancer Treatment and …, 2021 - Elsevier
Angiogenesis plays an important role in the development of cancer since it allows for the
delivery of oxygen, nutrients, and growth factors as well as tumor dissemination to distant …

Is angiogenesis inhibition the Holy Grail of cancer therapy?

T Boehm-Viswanathan - Current Opinion in Oncology, 2000 - journals.lww.com
Over the last several decades, oncology research and cancer treatment have concentrated
primarily on the cancer cells. Unfortunately, despite the intensive quest to find new and more …

Antiangiogenesis drug design: multiple pathways targeting tumor vasculature

H Zhong, JP Bowen - Current medicinal chemistry, 2006 - ingentaconnect.com
The initiation, growth, and development of new blood vessels through angiogenesis are
essential for tumor growth. Tumor masses require access to blood vessels for a sufficient …

Angiogenic inhibitors: a new therapeutic strategy in oncology

G Gasparini, R Longo, M Toi, N Ferrara - Nature clinical practice …, 2005 - nature.com
Angiogenesis is a multistep, complex and tightly regulated process that is necessary for
tumor growth and metastasis. Based on data of preclinical models, several antiangiogenic …

[HTML][HTML] Inducing angiogenesis, a key step in cancer vascularization, and treatment approaches

H Saman, SS Raza, S Uddin, K Rasul - Cancers, 2020 - mdpi.com
Angiogenesis is a term that describes the formation of new blood and lymphatic vessels from
a pre-existing vasculature. This allows tumour cells to acquire sustenance in the form of …

[HTML][HTML] Mechanism and its regulation of tumor-induced angiogenesis

MK Gupta, RY Qin - World journal of gastroenterology: WJG, 2003 - ncbi.nlm.nih.gov
Tumor angiogenesis is the proliferation of a network of blood vessels that penetrates into
cancerous growths, supplying nutrients and oxygen and removing waste products. The …

Overview of angiogenesis: biologic implications for antiangiogenic therapy

LM Ellis, W Liu, SA Ahmad, F Fan, Y Do Jung… - Seminars in …, 2001 - Elsevier
Tumor angiogenesis is essential for the growth of primary and metastatic tumors. This
process requires the coordinated activities of multiple factors and cell types. For tumors to …

Angiogenesis: an update and potential drug approaches

M Abdelrahim, S Konduri, R Basha… - International …, 2010 - spandidos-publications.com
The therapeutic potential of targeting tumor endothelium and vascular supply is now widely
recognized to treat different diseases. One such disease is cancer; where endothelial cells …

Angiogenesis inhibitors: current strategies and future prospects

KM Cook, WD Figg - CA: a cancer journal for clinicians, 2010 - Wiley Online Library
Angiogenesis has become an attractive target for drug therapy because of its key role in
tumor growth. An extensive array of compounds is currently in preclinical development, with …