Perineuronal nets gain prominence for their role in learning, memory, and plasticity

HH Shen - Proceedings of the National Academy of …, 2018 - National Acad Sciences
Discovered in the late 1800s, this lattice-like element wraps around certain neurons and
shares some components with cartilage. But far from providing mere structural support …

Diverse functions of perineuronal nets

M Karetko, J Skangiel-Kramska - Acta neurobiologiae experimentalis, 2009 - ane.pl
Perineuronal nets represent well-organised components of the extracellular matrix, which
are surrounding cell bodies, dendrites, and axon segments of a particular class of neurones …

From molecules to behavior: Implications for perineuronal net remodeling in learning and memory

B Sanchez, P Kraszewski, S Lee… - Journal of …, 2023 - Wiley Online Library
Perineuronal nets (PNNs) are condensed extracellular matrix (ECM) structures found
throughout the central nervous system that regulate plasticity. They consist of a …

Perineuronal nets—a specialized form of extracellular matrix in the adult nervous system

MR Celio, I Blumcke - Brain Research Reviews, 1994 - Elsevier
Abstract One century ago, Camillo Golgi described 'perineuronal nets' enwrapping the cell
bodies and proximal dendrites of certain neurons in the adult mammalian central nervous …

Perineuronal nets: plasticity, protection, and therapeutic potential

AC Reichelt, DJ Hare, TJ Bussey, LM Saksida - Trends in neurosciences, 2019 - cell.com
The relationship between neurons and perineuronal nets (PNNs) is attracting attention as a
central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround …

Deconstructing the perineuronal net: cellular contributions and molecular composition of the neuronal extracellular matrix

KA Giamanco, RT Matthews - Neuroscience, 2012 - Elsevier
Perineuronal nets (PNNs) are lattice-like substructures of the neural extracellular matrix that
enwrap particular populations of neurons throughout the central nervous system. Previous …

Extracellular matrix and perineuronal nets in CNS repair

JCF Kwok, G Dick, D Wang… - Developmental …, 2011 - Wiley Online Library
A perineuronal net (PNN) is a layer of lattice‐like matrix which enwraps the surface of the
soma and dendrites, and in some cases the axon initial segments, in sub‐populations of …

Perineuronal nets: subtle structures with large implications

H Carceller, Y Gramuntell, P Klimczak… - The …, 2023 - journals.sagepub.com
Perineuronal nets (PNNs) are specialized structures of the extracellular matrix that surround
the soma and proximal dendrites of certain neurons in the central nervous system …

The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function

JW Fawcett, T Oohashi, T Pizzorusso - Nature Reviews Neuroscience, 2019 - nature.com
Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan
(CSPG)-containing structures that surround the soma and dendrites of various mammalian …

Perineuronal nets in brain physiology and disease

D Testa, A Prochiantz, AA Di Nardo - Seminars in cell & developmental …, 2019 - Elsevier
Perineuronal nets (PNNs) in the brain are condensed glycosaminoglycan-rich extracellular
matrix structures with heterogeneous composition yet specific organization. They typically …